Obsessive-compulsive symptoms in neurologic disease: A review

M. S. George, J. A. Melvin, C. H. Kellner

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Obsessive-compulsive disorder (OCD) is an increasingly recognized disorder with a prevalence of 2-3% (Robins et al., 1984). Once thought to be psychodynamic in origin, OCD is now generally recognized as having a neurobiological cause. Although the exact pathophysiology of OCD in its pure form remains unknown, there are numerous reports of obsessive-compulsive symptoms arising in the setting of known neurological disease. In this paper, we review the reported cases of obsessive-compulsive symptoms associated with neurologic diseases and outline the known facts about the underlying neurobiology of OCD. Finally, we synthesize these findings into a proposed theory of the pathophysiology of OCD, in both its pure form and when it accompanies other neurological illness.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalBehavioural Neurology
Issue number1
StatePublished - 1992
Externally publishedYes


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