Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene

Gary A. Heiman; Ruth Ottman; Rachel J. Saunders-Pullman; Laurie J. Ozelius; Neil J. Risch; Susan B. Bressman

doi:10.1002/ajmg.b.30431

Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene

Gary A. Heiman
, Ruth Ottman
, Rachel J. Saunders-Pullman
, Laurie J. Ozelius
, Neil J. Risch
, Susan B. Bressman

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are comorbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia.

Original language	English
Pages (from-to)	361-364
Number of pages	4
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	144
Issue number	3
DOIs	https://doi.org/10.1002/ajmg.b.30431
State	Published - 5 Apr 2007
Externally published	Yes

Keywords

Dystonia
Obsessive-compulsive disorder
Pleiotropy
Psychiatric manifestations
Variable expressivity

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10.1002/ajmg.b.30431

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abstract = "Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are comorbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia.",

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AU - Saunders-Pullman, Rachel J.

AU - Ozelius, Laurie J.

AU - Risch, Neil J.

AU - Bressman, Susan B.

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AB - Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are comorbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia.

KW - Dystonia

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KW - Pleiotropy

KW - Psychiatric manifestations

KW - Variable expressivity

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JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

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Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene

Abstract

Keywords

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