Obsessive-compulsive disorder in patients with schizophrenia or schizoaffective disorder

Objective: The authors evaluated the frequency of DSM-III-R obsessive- compulsive disorder in patients with a primary diagnosis of schizophrenia or schizoaffective disorder. Method: Patients with schizophrenia (N=52) or schizoaffective disorder (N=25) were evaluated for the presence of obsessions and compulsions by means of the Structured Clinical Interview for DSM-III-R, the Yale-Brown Obsessive Compulsive Scale, chart review, and contact with the treating clinicians. Results: Six (7.8%) of the 77 patients met the DSM-III- R criteria for both obsessive-compulsive disorder and schizophrenia or schizoaffective disorder. Conclusions: These findings suggest that obsessive- compulsive disorder occurs in a substantial percentage of patients with schizophrenia or schizoaffective disorder. The addition of medications targeted at obsessive-compulsive disorder may be beneficial to these patients but requires systematic evaluation.