Observation of corneal transplantation in peripheral corneal disease postoperatively

Yibing Zhang, Yuan Hu, Xiaodong Li, Xiaoru Shi, Feihong Xu, Hui Jia

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The aim of the present study was to investigate the role of the limbal stem cells in corneal epithelial homeostasis in patients with peripheral corneal disease who received corneal transplantation surgery. This retrospective study enrolled 85 patients (85 eyes) with peripheral corneal lesion who underwent corneal transplantation at Department of Ophthalmology in First Hospital of Jilin University, Jilin, China. All patients during each follow-up period were examined for best corrected visual acuity, corneal reconstruction (assessed by slit-lamp biomicroscopy), anterior segment optical coherence tomography, and confocal microscopy. Patients were followed up for 3.5±2.4 years. All patients had improved postoperative best corrected visual acuity. Neither vascularization nor conjunc-tivalization of the graft occurred. Scanning of the graft was covered by normal corneal epithelium as confirmed on the laser scanning in vivo confocal microscopy. No evidence of normal limbal was detected in any of the operation eyes. The limbal stem cells may not play a critical role during normal corneal epithelial turnover in patients with peripheral corneal disease following corneal transplantation surgery.

Original languageEnglish
Pages (from-to)5384-5388
Number of pages5
JournalExperimental and Therapeutic Medicine
Volume15
Issue number6
DOIs
StatePublished - Jun 2018
Externally publishedYes

Keywords

  • Conjunctivalization
  • Deep anterior lamellar keratoplasty
  • Limbal stem cell
  • Penetrating keratoplasty

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