Object recognition deficit in Alzheimer's disease: Possible disconnection of the occipito-temporal component of the visual system

Patrick R. Hof; Constantin Bouras

doi:10.1016/0304-3940(91)90191-U

Object recognition deficit in Alzheimer's disease: Possible disconnection of the occipito-temporal component of the visual system

Patrick R. Hof, Constantin Bouras

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

An early object recognition impairment was observed in a patient presenting with a slowly progressive Alzheimer's disease. At autopsy, the cerebral cortex showed increased neuritic plaque and neurofibrillary tangle counts, particularly in the occipital and temporal lobes as compared to Alzheimer's disease cases with the usual clinical presentation and distribution of the neuropathological lesions (i.e., no early visual deficits and fewer pathological profiles in the occipital cortical areas than frontal or posterior parietal areas). This observation further supports the hypothesis that long corticocortical projections are selectively damaged in Alzheimer's disease and that the resulting disconnections may underlie specific neurological symptoms.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	Neuroscience Letters
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90191-U
State	Published - 14 Jan 1991

Keywords

Alzheimer's disease
Corticocortical projection
Human neocortex
Quantitative neuroanatomy
Vision

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10.1016/0304-3940(91)90191-U

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title = "Object recognition deficit in Alzheimer's disease: Possible disconnection of the occipito-temporal component of the visual system",

abstract = "An early object recognition impairment was observed in a patient presenting with a slowly progressive Alzheimer's disease. At autopsy, the cerebral cortex showed increased neuritic plaque and neurofibrillary tangle counts, particularly in the occipital and temporal lobes as compared to Alzheimer's disease cases with the usual clinical presentation and distribution of the neuropathological lesions (i.e., no early visual deficits and fewer pathological profiles in the occipital cortical areas than frontal or posterior parietal areas). This observation further supports the hypothesis that long corticocortical projections are selectively damaged in Alzheimer's disease and that the resulting disconnections may underlie specific neurological symptoms.",

keywords = "Alzheimer's disease, Corticocortical projection, Human neocortex, Quantitative neuroanatomy, Vision",

author = "Hof, {Patrick R.} and Constantin Bouras",

note = "Funding Information: We thank M. Surini, B. Greggio, R. Guntern, and R. Woolley for expert technical assistance, Dr W.G. Young for software development of our computer assisted microscope, and Dr J.H. Morrison for helpful comments on the manuscript. This work was supported by a fellowship from Fonds National Suisse de la Recherche Scien-tifique (83.495.0.87) to P.R.H.",

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doi = "10.1016/0304-3940(91)90191-U",

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N2 - An early object recognition impairment was observed in a patient presenting with a slowly progressive Alzheimer's disease. At autopsy, the cerebral cortex showed increased neuritic plaque and neurofibrillary tangle counts, particularly in the occipital and temporal lobes as compared to Alzheimer's disease cases with the usual clinical presentation and distribution of the neuropathological lesions (i.e., no early visual deficits and fewer pathological profiles in the occipital cortical areas than frontal or posterior parietal areas). This observation further supports the hypothesis that long corticocortical projections are selectively damaged in Alzheimer's disease and that the resulting disconnections may underlie specific neurological symptoms.

AB - An early object recognition impairment was observed in a patient presenting with a slowly progressive Alzheimer's disease. At autopsy, the cerebral cortex showed increased neuritic plaque and neurofibrillary tangle counts, particularly in the occipital and temporal lobes as compared to Alzheimer's disease cases with the usual clinical presentation and distribution of the neuropathological lesions (i.e., no early visual deficits and fewer pathological profiles in the occipital cortical areas than frontal or posterior parietal areas). This observation further supports the hypothesis that long corticocortical projections are selectively damaged in Alzheimer's disease and that the resulting disconnections may underlie specific neurological symptoms.

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KW - Corticocortical projection

KW - Human neocortex

KW - Quantitative neuroanatomy

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Object recognition deficit in Alzheimer's disease: Possible disconnection of the occipito-temporal component of the visual system

Abstract

Keywords

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