Obesity-related cognitive impairment: The role of endothelial dysfunction

Joy Jones Buie; Luke S. Watson; Crystal J. Smith; Catrina Sims-Robinson

doi:10.1016/j.nbd.2019.104580

Obesity-related cognitive impairment: The role of endothelial dysfunction

Joy Jones Buie
, Luke S. Watson
, Crystal J. Smith
, Catrina Sims-Robinson

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk factor for the development of cognitive impairment. In this review, we present evidence from clinical and preclinical studies supporting a role for obesity in cognitive impairment. Next, we discuss how obesity-related hyperinsulinemia/insulin resistance, systemic inflammation, and gut dysbiosis lead to cognitive impairment through induction of endothelial dysfunction and disruption of the blood brain barrier. Finally, we outline the potential clinical utility of dietary interventions, exercise, and bariatric surgery in circumventing the impacts of obesity on cognitive function.

Original language	English
Article number	104580
Journal	Neurobiology of Disease
Volume	132
DOIs	https://doi.org/10.1016/j.nbd.2019.104580
State	Published - Dec 2019
Externally published	Yes

Keywords

diet
gut dysbiosis
hyperinsulinemia
inflammation
insulin resistance
memory

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title = "Obesity-related cognitive impairment: The role of endothelial dysfunction",

abstract = "Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk factor for the development of cognitive impairment. In this review, we present evidence from clinical and preclinical studies supporting a role for obesity in cognitive impairment. Next, we discuss how obesity-related hyperinsulinemia/insulin resistance, systemic inflammation, and gut dysbiosis lead to cognitive impairment through induction of endothelial dysfunction and disruption of the blood brain barrier. Finally, we outline the potential clinical utility of dietary interventions, exercise, and bariatric surgery in circumventing the impacts of obesity on cognitive function.",

keywords = "diet, gut dysbiosis, hyperinsulinemia, inflammation, insulin resistance, memory",

author = "Buie, \{Joy Jones\} and Watson, \{Luke S.\} and Smith, \{Crystal J.\} and Catrina Sims-Robinson",

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year = "2019",

month = dec,

doi = "10.1016/j.nbd.2019.104580",

language = "English",

volume = "132",

journal = "Neurobiology of Disease",

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T1 - Obesity-related cognitive impairment

T2 - The role of endothelial dysfunction

AU - Buie, Joy Jones

AU - Watson, Luke S.

AU - Smith, Crystal J.

AU - Sims-Robinson, Catrina

PY - 2019/12

Y1 - 2019/12

N2 - Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk factor for the development of cognitive impairment. In this review, we present evidence from clinical and preclinical studies supporting a role for obesity in cognitive impairment. Next, we discuss how obesity-related hyperinsulinemia/insulin resistance, systemic inflammation, and gut dysbiosis lead to cognitive impairment through induction of endothelial dysfunction and disruption of the blood brain barrier. Finally, we outline the potential clinical utility of dietary interventions, exercise, and bariatric surgery in circumventing the impacts of obesity on cognitive function.

AB - Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk factor for the development of cognitive impairment. In this review, we present evidence from clinical and preclinical studies supporting a role for obesity in cognitive impairment. Next, we discuss how obesity-related hyperinsulinemia/insulin resistance, systemic inflammation, and gut dysbiosis lead to cognitive impairment through induction of endothelial dysfunction and disruption of the blood brain barrier. Finally, we outline the potential clinical utility of dietary interventions, exercise, and bariatric surgery in circumventing the impacts of obesity on cognitive function.

KW - diet

KW - gut dysbiosis

KW - hyperinsulinemia

KW - inflammation

KW - insulin resistance

KW - memory

UR - https://www.scopus.com/pages/publications/85071874071

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DO - 10.1016/j.nbd.2019.104580

M3 - Review article

C2 - 31454547

AN - SCOPUS:85071874071

SN - 0969-9961

VL - 132

JO - Neurobiology of Disease

JF - Neurobiology of Disease

M1 - 104580

ER -

Obesity-related cognitive impairment: The role of endothelial dysfunction

Abstract

Keywords

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