Obesity, Inflammatory Signaling, and Hepatocellular Carcinoma-An Enlarging Link

Sara Toffanin; Scott L. Friedman; Josep M. Llovet

doi:10.1016/j.ccr.2010.01.018

Obesity, Inflammatory Signaling, and Hepatocellular Carcinoma-An Enlarging Link

Research output: Contribution to journal › Short survey › peer-review

51 Scopus citations

Abstract

There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.

Original language	English
Pages (from-to)	115-117
Number of pages	3
Journal	Cancer Cell
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.ccr.2010.01.018
State	Published - 17 Feb 2010

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@article{5d95ea76cc884343b8d92c33589c25d1,

title = "Obesity, Inflammatory Signaling, and Hepatocellular Carcinoma-An Enlarging Link",

abstract = "There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.",

author = "Sara Toffanin and Friedman, \{Scott L.\} and Llovet, \{Josep M.\}",

note = "Funding Information: J.M.L. has grants from National Institute of Health, NIDDK 1R01DK076986-01, National Institute of Health (Spain) grant I+D Program (SAF-2007-61898), and Samuel Waxman Cancer Research Foundation. J.M.L. and the HCC Consortium are recipients of the AACR-Landon Innovator International award. S.L.F. has grants from the National Institutes of Health (1RO1DK37340 and 1RO1DK56621).",

year = "2010",

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day = "17",

doi = "10.1016/j.ccr.2010.01.018",

language = "English",

volume = "17",

pages = "115--117",

journal = "Cancer Cell",

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T1 - Obesity, Inflammatory Signaling, and Hepatocellular Carcinoma-An Enlarging Link

AU - Toffanin, Sara

AU - Friedman, Scott L.

AU - Llovet, Josep M.

N1 - Funding Information: J.M.L. has grants from National Institute of Health, NIDDK 1R01DK076986-01, National Institute of Health (Spain) grant I+D Program (SAF-2007-61898), and Samuel Waxman Cancer Research Foundation. J.M.L. and the HCC Consortium are recipients of the AACR-Landon Innovator International award. S.L.F. has grants from the National Institutes of Health (1RO1DK37340 and 1RO1DK56621).

PY - 2010/2/17

Y1 - 2010/2/17

N2 - There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.

AB - There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.

UR - https://www.scopus.com/pages/publications/76549084356

U2 - 10.1016/j.ccr.2010.01.018

DO - 10.1016/j.ccr.2010.01.018

M3 - Short survey

AN - SCOPUS:76549084356

SN - 1535-6108

VL - 17

SP - 115

EP - 117

JO - Cancer Cell

JF - Cancer Cell

IS - 2

ER -

Obesity, Inflammatory Signaling, and Hepatocellular Carcinoma-An Enlarging Link

Abstract

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