Obesity and colorectal adenomatous polyps

Alfred I. Neugu; Won Chul Lee; Gail C. Garbowski; Jerome D. Waye; Kenneth A. Forde; Michael R. Treat; Cecilia Fenoglio-preiser

doi:10.1093/jnci/83.5.359

Obesity and colorectal adenomatous polyps

Alfred I. Neugu, Won Chul Lee, Gail C. Garbowski, Jerome D. Waye, Kenneth A. Forde, Michael R. Treat, Cecilia Fenoglio-preiser

Center for Advanced Colonoscopy and Therapeutic Endoscopy at Mount Sinai (CACTES)

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Obesity has been investigated as a risk factor for various malignancies, including colon cancer. A case-control study was conducted on patients in three colonoscopy practices in New York City to determine possible risk factors for colorectal adenomatous polyps, a known precursor lesion for most cases of colorectal cancer. Among 301 case subjects with incident adenomatous polyps (174 men and 127 women) and 506 control subjects (223 men and 283 women), an increased risk was observed with increasing body mass index in women (odds ratio 2.1, 95% confidence interval 1.1-4.0; for highest versus lowest quartile, linear trend P =.02). A nonsignificant trend was observed for men. The increased risk seen in women is consistent with prior observations regarding reproductive hormonal and dietary risk factors for colorectal cancer. [J Natl Cancer Inst 83:359-361, 1991].

Original language	English
Pages (from-to)	359-361
Number of pages	3
Journal	Journal of the National Cancer Institute
Volume	83
Issue number	5
DOIs	https://doi.org/10.1093/jnci/83.5.359
State	Published - 6 Mar 1991

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title = "Obesity and colorectal adenomatous polyps",

abstract = "Obesity has been investigated as a risk factor for various malignancies, including colon cancer. A case-control study was conducted on patients in three colonoscopy practices in New York City to determine possible risk factors for colorectal adenomatous polyps, a known precursor lesion for most cases of colorectal cancer. Among 301 case subjects with incident adenomatous polyps (174 men and 127 women) and 506 control subjects (223 men and 283 women), an increased risk was observed with increasing body mass index in women (odds ratio 2.1, 95% confidence interval 1.1-4.0; for highest versus lowest quartile, linear trend P =.02). A nonsignificant trend was observed for men. The increased risk seen in women is consistent with prior observations regarding reproductive hormonal and dietary risk factors for colorectal cancer. [J Natl Cancer Inst 83:359-361, 1991].",

author = "Neugu, {Alfred I.} and Lee, {Won Chul} and Garbowski, {Gail C.} and Waye, {Jerome D.} and Forde, {Kenneth A.} and Treat, {Michael R.} and Cecilia Fenoglio-preiser",

note = "Funding Information: Supported in part by Public Health Service grant CA-37196 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, and from the Aaron Diamond Foundation. A. I. Neugut is the recipient of a Preventive Oncology Academic Award KO7-CA-01211 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services.",

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AU - Lee, Won Chul

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AU - Waye, Jerome D.

AU - Forde, Kenneth A.

AU - Treat, Michael R.

AU - Fenoglio-preiser, Cecilia

N1 - Funding Information: Supported in part by Public Health Service grant CA-37196 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, and from the Aaron Diamond Foundation. A. I. Neugut is the recipient of a Preventive Oncology Academic Award KO7-CA-01211 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services.

PY - 1991/3/6

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N2 - Obesity has been investigated as a risk factor for various malignancies, including colon cancer. A case-control study was conducted on patients in three colonoscopy practices in New York City to determine possible risk factors for colorectal adenomatous polyps, a known precursor lesion for most cases of colorectal cancer. Among 301 case subjects with incident adenomatous polyps (174 men and 127 women) and 506 control subjects (223 men and 283 women), an increased risk was observed with increasing body mass index in women (odds ratio 2.1, 95% confidence interval 1.1-4.0; for highest versus lowest quartile, linear trend P =.02). A nonsignificant trend was observed for men. The increased risk seen in women is consistent with prior observations regarding reproductive hormonal and dietary risk factors for colorectal cancer. [J Natl Cancer Inst 83:359-361, 1991].

AB - Obesity has been investigated as a risk factor for various malignancies, including colon cancer. A case-control study was conducted on patients in three colonoscopy practices in New York City to determine possible risk factors for colorectal adenomatous polyps, a known precursor lesion for most cases of colorectal cancer. Among 301 case subjects with incident adenomatous polyps (174 men and 127 women) and 506 control subjects (223 men and 283 women), an increased risk was observed with increasing body mass index in women (odds ratio 2.1, 95% confidence interval 1.1-4.0; for highest versus lowest quartile, linear trend P =.02). A nonsignificant trend was observed for men. The increased risk seen in women is consistent with prior observations regarding reproductive hormonal and dietary risk factors for colorectal cancer. [J Natl Cancer Inst 83:359-361, 1991].

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JO - Journal of the National Cancer Institute

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Obesity and colorectal adenomatous polyps

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