Obese young men have elevated plasma estrogen levels but obese premenopausal women do not

Barnett Zumoff, Gladys W. Strain, Jacob Kream, John O'Connor, Joseph Levin, David K. Fukushima

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The 24 hr mean plasma concentrations of estrone (E1) and estradiol (E2) were measured in 18 healthy, regularly cycling obese women; 16 healthy, regularly cycling nonobese women; 18 healthy obese men; and 33 healthy nonobese men. The obese men showed significant elevations of both E1 (67 pg/ml versus 49 pg/ml control; P < 0.005) and E2 (37 pg/ml versus 28 pg/ml; P < 0.005), but the obese women showed no significant elevation of either E1 or E2. The most likely explanation for the absence of significant hyperestrogenemia in the obese women despite evidence that such women have increased androstenedione-to-estrone conversion is that the latter source of estrogen is too small in comparison with estradiol secretion to cause a statistically detectable increment in plasma estrogen levels.

Original languageEnglish
Pages (from-to)1011-1014
Number of pages4
JournalMetabolism: Clinical and Experimental
Volume30
Issue number10
DOIs
StatePublished - Oct 1981
Externally publishedYes

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