Abstract
To the Editor: The article by Swain et al. (Jan. 18 issue)1 on the effect of oat bran on lipoprotein levels suffers from several fatal flaws. First, this study violates one of the principles of clinical trials: that the intervention should be of sufficient magnitude to have a measurable effect on outcome.2 Although 100 g of oat bran was to be administered daily to the study group, the mean intake was actually only 38.9 g per day. This is far below the 60 to 100 g per day administered in studies that have shown a lipid-lowering effect of oat bran.
Original language | English |
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Pages (from-to) | 1746-1749 |
Number of pages | 4 |
Journal | New England Journal of Medicine |
Volume | 322 |
Issue number | 24 |
DOIs | |
State | Published - 14 Jun 1990 |
Externally published | Yes |