Nucleotide sequence of the transforming gene of avian myeloblastosis virus

Keith E. Rushlow; James A. Lautenberger; Takis S. Papas; Marcel A. Baluda; Bernard Perbal; Jack G. Chirikjian; E. Premkumar Reddy

doi:10.1126/science.6283631

Nucleotide sequence of the transforming gene of avian myeloblastosis virus

Keith E. Rushlow, James A. Lautenberger, Takis S. Papas, Marcel A. Baluda, Bernard Perbal, Jack G. Chirikjian, E. Premkumar Reddy

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Avian myeloblastosis virus is defective in reproductive capacity, requiring a helper virus to provide the viral proteins essential for synthesis of new infectious virus. This virus arose by recombination of the nondefective helper virus and host cellular sequences present within the normal avian genome. These latter sequences are essential for leukemogenic activity. The complete nucleotide sequence of this region is reported. Within the acquired cellular sequences there is an open reading frame of 795 nucleotides starting with the initiation codon ATG (adenine, thymine, guanine) and terminating with the triplet TAG. This open reading frame could code for the putative transforming protein of 265 amino acids with a molecular weight of approximately 30,000.

Original language	English
Pages (from-to)	1421-1423
Number of pages	3
Journal	Science
Volume	216
Issue number	4553
DOIs	https://doi.org/10.1126/science.6283631
State	Published - 1982
Externally published	Yes

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title = "Nucleotide sequence of the transforming gene of avian myeloblastosis virus",

abstract = "Avian myeloblastosis virus is defective in reproductive capacity, requiring a helper virus to provide the viral proteins essential for synthesis of new infectious virus. This virus arose by recombination of the nondefective helper virus and host cellular sequences present within the normal avian genome. These latter sequences are essential for leukemogenic activity. The complete nucleotide sequence of this region is reported. Within the acquired cellular sequences there is an open reading frame of 795 nucleotides starting with the initiation codon ATG (adenine, thymine, guanine) and terminating with the triplet TAG. This open reading frame could code for the putative transforming protein of 265 amino acids with a molecular weight of approximately 30,000.",

author = "Rushlow, {Keith E.} and Lautenberger, {James A.} and Papas, {Takis S.} and Baluda, {Marcel A.} and Bernard Perbal and Chirikjian, {Jack G.} and Reddy, {E. Premkumar}",

year = "1982",

doi = "10.1126/science.6283631",

language = "English",

volume = "216",

pages = "1421--1423",

journal = "Science",

issn = "0036-8075",

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T1 - Nucleotide sequence of the transforming gene of avian myeloblastosis virus

AU - Rushlow, Keith E.

AU - Lautenberger, James A.

AU - Papas, Takis S.

AU - Baluda, Marcel A.

AU - Perbal, Bernard

AU - Chirikjian, Jack G.

AU - Reddy, E. Premkumar

PY - 1982

Y1 - 1982

N2 - Avian myeloblastosis virus is defective in reproductive capacity, requiring a helper virus to provide the viral proteins essential for synthesis of new infectious virus. This virus arose by recombination of the nondefective helper virus and host cellular sequences present within the normal avian genome. These latter sequences are essential for leukemogenic activity. The complete nucleotide sequence of this region is reported. Within the acquired cellular sequences there is an open reading frame of 795 nucleotides starting with the initiation codon ATG (adenine, thymine, guanine) and terminating with the triplet TAG. This open reading frame could code for the putative transforming protein of 265 amino acids with a molecular weight of approximately 30,000.

AB - Avian myeloblastosis virus is defective in reproductive capacity, requiring a helper virus to provide the viral proteins essential for synthesis of new infectious virus. This virus arose by recombination of the nondefective helper virus and host cellular sequences present within the normal avian genome. These latter sequences are essential for leukemogenic activity. The complete nucleotide sequence of this region is reported. Within the acquired cellular sequences there is an open reading frame of 795 nucleotides starting with the initiation codon ATG (adenine, thymine, guanine) and terminating with the triplet TAG. This open reading frame could code for the putative transforming protein of 265 amino acids with a molecular weight of approximately 30,000.

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SN - 0036-8075

VL - 216

SP - 1421

EP - 1423

JO - Science

JF - Science

IS - 4553

ER -

Nucleotide sequence of the transforming gene of avian myeloblastosis virus

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