Nucleoside phosphorylase 2 (Np-2) of mice

Theodore A. Bremner, E. Premkumar-Reddy, Kunjuraman Nayar, Richard E. Kouri

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Isozyme patterns of nucleoside phosphorylase (NP) in 16 inbred strains, two recombinant inbred, one congenic, and three species of wild mice were studied. Evidence is provided for a genetic locus, Np-2, encoding an electrophoretic variant which is expressed exclusively in erythrocytes of certain inbred strains. This finding establishes the occurrence of genetic polymorphism of NP among inbred strains of mice. In addition, the Npla allele previously reported only in inbred strains has been observed in one of the species of wild mice (Mus musculus castaneus) studied.

Original languageEnglish
Pages (from-to)1143-1151
Number of pages9
JournalBiochemical Genetics
Volume16
Issue number11-12
DOIs
StatePublished - Dec 1978
Externally publishedYes

Keywords

  • electrophoresis
  • genetic polymorphism
  • mouse
  • nucleoside phosphorylase 2
  • starch gel

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