TY - JOUR
T1 - Novel triple-reassortant influenza viruses in pigs, Guangxi, China article
AU - He, Ping
AU - Wang, Guojun
AU - Mo, Yanning
AU - Yu, Qingxiong
AU - Xiao, Xiong
AU - Yang, Wenjuan
AU - Zhao, Weifeng
AU - Guo, Xuan
AU - Chen, Qiong
AU - He, Jianqiao
AU - Liang, Mingli
AU - Zhu, Jian
AU - Ding, Yangbao
AU - Wei, Zuzhang
AU - Ouyang, Kang
AU - Liu, Fang
AU - Jian, Hui
AU - Huang, Weijian
AU - García-Sastre, Adolfo
AU - Chen, Ying
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Considered a "mixing vessel" for influenza viruses, pigs can give rise to new influenza virus reassortants that can threaten humans. During our surveillance of pigs in Guangxi, China from 2013 to 2015, we isolated 11 H1N1 and three H3N2 influenza A viruses of swine origin (IAVs-S). Out of the 14, we detected ten novel triple-reassortant viruses, which contained surface genes (hemagglutinin and neuraminidase) from Eurasian avian-like (EA) H1N1 or seasonal human-like H3N2, matrix (M) genes from H1N1/2009 pandemic or EA H1N1, nonstructural (NS) genes from classical swine, and the remaining genes from H1N1/2009 pandemic. Mouse studies indicate that these IAVs-S replicate efficiently without prior adaptation, with some isolates demonstrating lethality. Notably, the reassortant EA H1N1 viruses with EA-like M gene have been reported in human infections. Further investigations will help to assess the potential risk of these novel triple-reassortant viruses to humans.
AB - Considered a "mixing vessel" for influenza viruses, pigs can give rise to new influenza virus reassortants that can threaten humans. During our surveillance of pigs in Guangxi, China from 2013 to 2015, we isolated 11 H1N1 and three H3N2 influenza A viruses of swine origin (IAVs-S). Out of the 14, we detected ten novel triple-reassortant viruses, which contained surface genes (hemagglutinin and neuraminidase) from Eurasian avian-like (EA) H1N1 or seasonal human-like H3N2, matrix (M) genes from H1N1/2009 pandemic or EA H1N1, nonstructural (NS) genes from classical swine, and the remaining genes from H1N1/2009 pandemic. Mouse studies indicate that these IAVs-S replicate efficiently without prior adaptation, with some isolates demonstrating lethality. Notably, the reassortant EA H1N1 viruses with EA-like M gene have been reported in human infections. Further investigations will help to assess the potential risk of these novel triple-reassortant viruses to humans.
UR - http://www.scopus.com/inward/record.url?scp=85047086157&partnerID=8YFLogxK
U2 - 10.1038/s41426-018-0088-z
DO - 10.1038/s41426-018-0088-z
M3 - Article
C2 - 29765037
AN - SCOPUS:85047086157
SN - 2222-1751
VL - 7
JO - Emerging Microbes and Infections
JF - Emerging Microbes and Infections
IS - 1
M1 - 85
ER -