TY - JOUR
T1 - Novel therapeutics in myocardial infarction
T2 - Targeting microvascular dysfunction and reperfusion injury
AU - Fordyce, Christopher B.
AU - Gersh, Bernard J.
AU - Stone, Gregg W.
AU - Granger, Christopher B.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/9/12
Y1 - 2015/9/12
N2 - Despite the large number of novel therapies under basic scientific investigation, the translation of cardioprotective strategies targeting reperfusion injury to improve patient outcomes following percutaneous coronary intervention (PCI) for myocardial infarction (MI) has been disappointing. The varying susceptibility of an individual to reperfusion injury, as well as the narrow window of opportunity in which to intervene, adds significant complexity. Here, we discuss the unmet need and challenges of translating cardioprotective strategies into clinical practice, review the pathophysiology of microvascular dysfunction and lethal reperfusion as they relate to promising novel therapeutics, and evaluate recent and ongoing clinical trials in the field.
AB - Despite the large number of novel therapies under basic scientific investigation, the translation of cardioprotective strategies targeting reperfusion injury to improve patient outcomes following percutaneous coronary intervention (PCI) for myocardial infarction (MI) has been disappointing. The varying susceptibility of an individual to reperfusion injury, as well as the narrow window of opportunity in which to intervene, adds significant complexity. Here, we discuss the unmet need and challenges of translating cardioprotective strategies into clinical practice, review the pathophysiology of microvascular dysfunction and lethal reperfusion as they relate to promising novel therapeutics, and evaluate recent and ongoing clinical trials in the field.
KW - coronary microcirculation
KW - myocardial infarction
KW - novel therapeutics
KW - reperfusion injury
UR - https://www.scopus.com/pages/publications/84941314655
U2 - 10.1016/j.tips.2015.06.004
DO - 10.1016/j.tips.2015.06.004
M3 - Review article
C2 - 26148636
AN - SCOPUS:84941314655
SN - 0165-6147
VL - 36
SP - 605
EP - 616
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 9
ER -