Novel therapeutics for systemic lupus erythematosus

Margrit Wiesendanger, Anfisa Stanevsky, Susan Kovsky, Betty Diamond

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Purpose of review: This review provides an update on recently explored therapies in systemic lupus erythematosus and introduces novel therapeutic approaches under consideration. Recent advances in our understanding of systemic lupus are highlighted as well, as these must now inform consideration of therapeutics. Recent findings: Many therapeutic strategies have been shown to be beneficial in murine models of lupus. Compounds that inhibit cellular signaling in response to autoantigens or other triggers and protocols that reconstitute the immune repertoire to diminish autoreactivity are now entering clinical trials. Summary: Requirements for novel approaches in lupus include improved efficacy and lower toxicity than current therapies, with the goal to reduce tissue damage while preserving immunocompetence.

Original languageEnglish
Pages (from-to)227-235
Number of pages9
JournalCurrent Opinion in Rheumatology
Issue number3
StatePublished - May 2006
Externally publishedYes


  • Immune activation
  • Immunosuppression
  • Systemic lupus erythematosus
  • Target organ injury
  • Therapy


Dive into the research topics of 'Novel therapeutics for systemic lupus erythematosus'. Together they form a unique fingerprint.

Cite this