Novel roles of complement in T effector cell regulation

Peter S. Heeger, Claudia Kemper

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immunemodulation during a T cell response.

Original languageEnglish
Pages (from-to)216-224
Number of pages9
JournalImmunobiology
Volume217
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • Autoimmunity
  • C3a
  • C5a
  • CD46
  • Complement
  • T cell
  • Transplantation

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