@inbook{480d23df53bb407c89b67285227f4a98,
title = "Novel omics technology driving translational research in precision oncology",
abstract = "In this review, we summarize the current challenges faced by cancer researchers and motivate the use of novel genomics solutions. We follow this up with a comprehensive overview of three recent genomics technologies: liquid biopsy, single-cell RNA sequencing and spatial transcriptomics. We discuss a few representative protocols/assays for each technology along with their strengths, weaknesses, optimal use-cases, and their current stage of clinical deployment by summarizing trial data. We focus on how these technologies help us develop a better understanding of cancer as a rapidly evolving heterogeneous genetic disease that modulates its immediate microenvironment leading to systemic macro-level changes in the patient body. We summarize the review with a flowchart that integrates these three technologies in the existing workflows of clinicians and researchers toward robust detection, accurate diagnosis, and precision oncology.",
keywords = "Cancer heterogeneity, Genomics use case in translational research, Liquid biopsy, Precision oncology, Single-cell sequencing, Spatial transcriptomics",
author = "Anubhav Basu and Anshul Budhraja and Juwayria and Dasari Abhilash and Ishaan Gupta",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = jan,
doi = "10.1016/bs.adgen.2021.08.003",
language = "English",
isbn = "9780128237854",
series = "Advances in Genetics",
publisher = "Academic Press Inc.",
pages = "81--145",
editor = "Dhavendra Kumar",
booktitle = "Advances in Genetics",
address = "United States",
}