Novel Non-Protein Biomarkers for Early Detection of Hepatocellular Carcinoma

Ghassan K. Abou-Alfa, Lin Wu, Augusto Villanueva

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Early detection of hepatocellular carcinoma (HCC) while in its early stages is critical for reducing HCC mortality in high-risk patients. However, highly sensitive and specific surveillance biomarkers for early-stage HCC detection are still lacking. In recent years, great efforts have been made to research tumor-derived molecular features that are detectable in circulation, such as circulating tumor deoxyribonucleic acid and circulating tumor ribonucleic acid, in order to explore their potential as non-invasive biomarker candidates in many tumor types. In this review, we summarize current studies on these new approaches and their application in early HCC detection.

Original languageEnglish
Pages (from-to)1369-1374
Number of pages6
Issue number10
StatePublished - Oct 2021


  • Biomarkers
  • Early detection
  • Hepatocellular carcinoma
  • Liquid biopsy


Dive into the research topics of 'Novel Non-Protein Biomarkers for Early Detection of Hepatocellular Carcinoma'. Together they form a unique fingerprint.

Cite this