Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

Jiechen Yin, Xiang Li, Joe Jing, Jiawen Li, David Mukai, Sari Mahon, Ahmad Edris, Khiet Hoang, K. Kirk Shung, Matthew Brenner, Jagat Narula, Qifa Zhou, Zhongping Chen

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.

Original languageEnglish
Article number060505
JournalJournal of Biomedical Optics
Volume16
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Integrated dual-modality imaging system
  • Intravascular ultrasound
  • Optical coherence tomography

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