Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

Jiechen Yin; Xiang Li; Joe Jing; Jiawen Li; David Mukai; Sari Mahon; Ahmad Edris; Khiet Hoang; K. Kirk Shung; Matthew Brenner; Jagat Narula; Qifa Zhou; Zhongping Chen

doi:10.1117/1.3589097

Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

Jiechen Yin, Xiang Li, Joe Jing, Jiawen Li, David Mukai, Sari Mahon, Ahmad Edris, Khiet Hoang, K. Kirk Shung, Matthew Brenner, Jagat Narula, Qifa Zhou, Zhongping Chen

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.

Original language	English
Article number	060505
Journal	Journal of Biomedical Optics
Volume	16
Issue number	6
DOIs	https://doi.org/10.1117/1.3589097
State	Published - Jun 2011
Externally published	Yes

Keywords

Integrated dual-modality imaging system
Intravascular ultrasound
Optical coherence tomography

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title = "Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging",

abstract = "We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.",

keywords = "Integrated dual-modality imaging system, Intravascular ultrasound, Optical coherence tomography",

author = "Jiechen Yin and Xiang Li and Joe Jing and Jiawen Li and David Mukai and Sari Mahon and Ahmad Edris and Khiet Hoang and {Kirk Shung}, K. and Matthew Brenner and Jagat Narula and Qifa Zhou and Zhongping Chen",

note = "Funding Information: We would like to thank Ms. Tanya Burney and Mr. David Yoon for their assistance during the surgical procedure. This work is based on research supported by the NIH (Grant Nos. R01EB10090, R01EB-00293, R01HL105215, RR-01192, and P41-EB2182) and the U.S. Air Force Office of Scientific Research, Medical Free-Electron Laser Program Grant No. FA9550-08-1-0384. Xiang Li is partially supported by USC Provost Fellowship. Institutional support from the Beckman Laser Institute Endowment is also gratefully acknowledged.",

year = "2011",

month = jun,

doi = "10.1117/1.3589097",

language = "English",

volume = "16",

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AU - Yin, Jiechen

AU - Li, Xiang

AU - Jing, Joe

AU - Li, Jiawen

AU - Mukai, David

AU - Mahon, Sari

AU - Edris, Ahmad

AU - Hoang, Khiet

AU - Kirk Shung, K.

AU - Brenner, Matthew

AU - Narula, Jagat

AU - Zhou, Qifa

AU - Chen, Zhongping

N1 - Funding Information: We would like to thank Ms. Tanya Burney and Mr. David Yoon for their assistance during the surgical procedure. This work is based on research supported by the NIH (Grant Nos. R01EB10090, R01EB-00293, R01HL105215, RR-01192, and P41-EB2182) and the U.S. Air Force Office of Scientific Research, Medical Free-Electron Laser Program Grant No. FA9550-08-1-0384. Xiang Li is partially supported by USC Provost Fellowship. Institutional support from the Beckman Laser Institute Endowment is also gratefully acknowledged.

PY - 2011/6

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N2 - We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.

AB - We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.

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Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

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