Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences

P. Nony; J. Tessier; G. Chadeuf; P. Ward; A. Giraud; M. Dugast; R. M. Linden; P. Moullier; A. Salvetti

doi:10.1128/JVI.75.20.9991-9994.2001

Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences

P. Nony, J. Tessier, G. Chadeuf, P. Ward, A. Giraud, M. Dugast, R. M. Linden, P. Moullier, A. Salvetti

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Abstract

This study identifies a region of the adeno-associated virus type 2 (AAV-2) rep gene (nucleotides 190 to 540 of wild-type AAV-2) as a cis-acting Rep-dependent element able to promote the replication of transiently transfected plasmids. This viral element is also shown to be involved in the amplification of integrated sequences in the presence of adenovirus and Rep proteins.

Original language	English
Pages (from-to)	9991-9994
Number of pages	4
Journal	Journal of Virology
Volume	75
Issue number	20
DOIs	https://doi.org/10.1128/JVI.75.20.9991-9994.2001
State	Published - 2001
Externally published	Yes

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10.1128/JVI.75.20.9991-9994.2001

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title = "Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences",

abstract = "This study identifies a region of the adeno-associated virus type 2 (AAV-2) rep gene (nucleotides 190 to 540 of wild-type AAV-2) as a cis-acting Rep-dependent element able to promote the replication of transiently transfected plasmids. This viral element is also shown to be involved in the amplification of integrated sequences in the presence of adenovirus and Rep proteins.",

author = "P. Nony and J. Tessier and G. Chadeuf and P. Ward and A. Giraud and M. Dugast and Linden, {R. M.} and P. Moullier and A. Salvetti",

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T1 - Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences

AU - Nony, P.

AU - Tessier, J.

AU - Chadeuf, G.

AU - Ward, P.

AU - Giraud, A.

AU - Dugast, M.

AU - Linden, R. M.

AU - Moullier, P.

AU - Salvetti, A.

PY - 2001

Y1 - 2001

N2 - This study identifies a region of the adeno-associated virus type 2 (AAV-2) rep gene (nucleotides 190 to 540 of wild-type AAV-2) as a cis-acting Rep-dependent element able to promote the replication of transiently transfected plasmids. This viral element is also shown to be involved in the amplification of integrated sequences in the presence of adenovirus and Rep proteins.

AB - This study identifies a region of the adeno-associated virus type 2 (AAV-2) rep gene (nucleotides 190 to 540 of wild-type AAV-2) as a cis-acting Rep-dependent element able to promote the replication of transiently transfected plasmids. This viral element is also shown to be involved in the amplification of integrated sequences in the presence of adenovirus and Rep proteins.

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U2 - 10.1128/JVI.75.20.9991-9994.2001

DO - 10.1128/JVI.75.20.9991-9994.2001

M3 - Article

C2 - 11559833

AN - SCOPUS:0034805974

SN - 0022-538X

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JO - Journal of Virology

JF - Journal of Virology

IS - 20

ER -

Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences

Abstract

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