Novel bladder-sparing approaches in patients with muscle-invasive bladder cancer

Research output: Contribution to journalReview articlepeer-review


The pursuit of surgeons and oncologists in fulfilling the inherent desire of patients to retain their urinary bladder despite having muscle-invasive bladder cancer (MIBC) has sparked years of research and multiple debates, given its aggressive nature and the high risk of fatal metastatic recurrence. Historically, several approaches to bladder-sparing treatment have been explored, ranging from radical transurethral resection to concurrent chemoradiation. A less well-established approach involves a risk-adapted approach with local therapy deferred based on the clinical response to transurethral resection followed by systemic therapy. Each approach is associated with potential risks, benefits, and trade-offs. In this review, we aim to understand, navigate, and suggest future perspectives on bladder-sparing approaches in patients with MIBC.

Original languageEnglish
JournalTrends in Molecular Medicine
StateAccepted/In press - 2024


  • anticancer drug combination
  • bladder cancer
  • immunotherapy
  • partial cystectomy
  • radical cystectomy
  • transurethral resection of bladder tumor


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