Note: Application of laser produced plasma Kα x-ray probe in radiation biology

Masaharu Nishikino; Katsutoshi Sato; Noboru Hasegawa; Masahiko Ishino; Shinsuke Ohshima; Yasuaki Okano; Tetsuya Kawachi; Hodaka Numasaki; Tetruki Teshima; Hiroaki Nishimura

doi:10.1063/1.3302827

Note: Application of laser produced plasma Kα x-ray probe in radiation biology

Masaharu Nishikino
, Katsutoshi Sato
, Noboru Hasegawa
, Masahiko Ishino
, Shinsuke Ohshima
, Yasuaki Okano
, Tetsuya Kawachi
, Hodaka Numasaki
, Tetruki Teshima
, Hiroaki Nishimura

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A dedicated radiation biology x-ray generation and exposure system has been developed. 8.0 keV in energy x-ray pulses generated with a femtosecond-laser pulse was used to irradiate sample cells through a custom-made culture dish with a silicon nitride membrane. The x-ray irradiation resulted in DNA double-strand breaks in the nucleus of a culture cell that were similar to those obtained with a conventional x-ray source, thus demonstrating the feasibility of radiobiological studies utilizing a single burst of x-rays focused on single cell specimens.

Original language	English
Article number	026107
Journal	Review of Scientific Instruments
Volume	81
Issue number	2
DOIs	https://doi.org/10.1063/1.3302827
State	Published - 2010
Externally published	Yes

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10.1063/1.3302827

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title = "Note: Application of laser produced plasma Kα x-ray probe in radiation biology",

abstract = "A dedicated radiation biology x-ray generation and exposure system has been developed. 8.0 keV in energy x-ray pulses generated with a femtosecond-laser pulse was used to irradiate sample cells through a custom-made culture dish with a silicon nitride membrane. The x-ray irradiation resulted in DNA double-strand breaks in the nucleus of a culture cell that were similar to those obtained with a conventional x-ray source, thus demonstrating the feasibility of radiobiological studies utilizing a single burst of x-rays focused on single cell specimens.",

author = "Masaharu Nishikino and Katsutoshi Sato and Noboru Hasegawa and Masahiko Ishino and Shinsuke Ohshima and Yasuaki Okano and Tetsuya Kawachi and Hodaka Numasaki and Tetruki Teshima and Hiroaki Nishimura",

year = "2010",

doi = "10.1063/1.3302827",

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T2 - Application of laser produced plasma Kα x-ray probe in radiation biology

AU - Nishikino, Masaharu

AU - Sato, Katsutoshi

AU - Hasegawa, Noboru

AU - Ishino, Masahiko

AU - Ohshima, Shinsuke

AU - Okano, Yasuaki

AU - Kawachi, Tetsuya

AU - Numasaki, Hodaka

AU - Teshima, Tetruki

AU - Nishimura, Hiroaki

PY - 2010

Y1 - 2010

N2 - A dedicated radiation biology x-ray generation and exposure system has been developed. 8.0 keV in energy x-ray pulses generated with a femtosecond-laser pulse was used to irradiate sample cells through a custom-made culture dish with a silicon nitride membrane. The x-ray irradiation resulted in DNA double-strand breaks in the nucleus of a culture cell that were similar to those obtained with a conventional x-ray source, thus demonstrating the feasibility of radiobiological studies utilizing a single burst of x-rays focused on single cell specimens.

AB - A dedicated radiation biology x-ray generation and exposure system has been developed. 8.0 keV in energy x-ray pulses generated with a femtosecond-laser pulse was used to irradiate sample cells through a custom-made culture dish with a silicon nitride membrane. The x-ray irradiation resulted in DNA double-strand breaks in the nucleus of a culture cell that were similar to those obtained with a conventional x-ray source, thus demonstrating the feasibility of radiobiological studies utilizing a single burst of x-rays focused on single cell specimens.

UR - https://www.scopus.com/pages/publications/77949287416

U2 - 10.1063/1.3302827

DO - 10.1063/1.3302827

M3 - Article

C2 - 20192524

AN - SCOPUS:77949287416

SN - 0034-6748

VL - 81

JO - Review of Scientific Instruments

JF - Review of Scientific Instruments

IS - 2

M1 - 026107

ER -

Note: Application of laser produced plasma Kα x-ray probe in radiation biology

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