NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Keyphrases

• C-Myc 100%
• Leukemic Cells 100%
• Cell Growth 100%
• Transcriptional Network 100%
• Feed-forward Loop 100%
• Notch1 100%
• Notch1 Signaling 50%
• Transcriptional Program 33%
• T-cell Acute Lymphoblastic Leukemia (T-ALL) 33%
• Tall Cell Variant 33%
• Oncogenic Signaling 16%
• T Cells 16%
• Gene Expression 16%
• Expression Profile 16%
• Signaling Pathway 16%
• Gene Regulatory Network 16%
• Transcriptional Response 16%
• T Cell Development 16%
• Gene Signature 16%
• Cell Size 16%
• MYC Gene 16%
• Gene Expression Array 16%
• Systems Biology Approach 16%
• Extracellular Signaling 16%
• Common Target 16%
• Reverse Engineering 16%
• Cell nucleus 16%
• Integrative Systems Biology 16%
• Biosynthetic Routes 16%
• ChIP-on-chip 16%
• Biosynthetic Pathway Genes 16%

Biochemistry, Genetics and Molecular Biology

• T Cell 100%
• Gene Expression 100%
• Cell Growth 100%
• Carcinogenesis 50%
• Anabolism 50%
• Cell Maturation 50%
• Gene Expression Profiling 50%
• Mediator 50%
• Regulatory Network 50%
• Cell Size 50%
• ChIP-on-chip 50%

Immunology and Microbiology

• Gene Expression 100%
• Cell Growth 100%
• T Cell 50%
• Mediator 50%
• T Cell Development 50%
• Cell Size 50%
• Cell Nucleus 50%
• Gene Expression Assay 50%