Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and Other Neurological Conditions

Ari Moskowitz, Yu Feng Yvonne Chan, Aneesh B. Singhal

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Original languageEnglish
Title of host publicationChemistry and Biochemistry of Oxygen Therapeutics
Subtitle of host publicationFrom Transfusion to Artificial Blood
PublisherJohn Wiley and Sons
Number of pages19
ISBN (Print)9780470686683
StatePublished - 4 Jul 2011
Externally publishedYes


  • Centers for Disease Control (CDC) estimates - cerebrovascular diseases, cause of death in the United States
  • HBO use in deep-sea divers - decompression sickness ("the bends") and arterial gas embolism
  • Hyperbaric oxygen therapy - and HBO use in organ ischemia
  • Hyperoxia, reducing cyclooxygenase-2 (COX-2) mRNA and MMP-9 - and intercellular adhesion molecule-1 (ICAM-1) levels
  • NBO therapy, accessible - costing less, pleasant for patients, than the HBO
  • Normobaric and hyperbaric oxygen therapy - ischemic stroke, other neurological conditions
  • Normobaric oxygen therapy - 100% oxygen at atmospheric pressure, via face mask
  • Oxygen therapy in acute ischemic stroke (AIS) - hyperoxia in cerebral ischemia
  • Preclinical testing, and therapeutic time window, dosage - in stroke subtypes

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