Normalization of nomenclature for peptide motifs as ligands of modular protein domains

Rein Aasland, Charles Abrams, Christophe Ampe, Linda J. Ball, Mark T. Bedford, Gianni Cesareni, Mario Gimona, James H. Hurley, Thomas Jarchau, Veli Pekka Lehto, Mark A. Lemmon, Rune Linding, Bruce J. Mayer, Makoto Nagai, Marius Sudol, Ulrich Walter, Steve J. Winder

Research output: Contribution to journalShort surveypeer-review

109 Scopus citations


We propose a normalization of symbols and terms used to describe, accurately and succinctly, the detailed interactions between amino acid residues of pairs of interacting proteins at protein:protein (or protein:peptide) interfaces. Our aim is to unify several diverse descriptions currently in use in order to facilitate communication in the rapidly progressing field of signaling by protein domains. In order for the nomenclature to be convenient and widely used, we also suggest a parallel set of symbols restricted to the ASCII format allowing accurate parsing of the nomenclature to a computer-readable form. This proposal will be reviewed in the future and will therefore be open for the inclusion of new rules, modifications and changes.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalFEBS Letters
Issue number1
StatePublished - 20 Feb 2002


  • ASCII format
  • Glossary
  • Nomenclature
  • Peptide motif
  • Protein domain, specificity and recognition
  • Protein-protein interaction
  • Proteomics


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