Normal versus high tension glaucoma: A comparison of functional and structural defects

Oraorn Thonginnetra, Vivienne C. Greenstein, David Chu, Jeffrey M. Liebmann, Robert Ritch, Donald C. Hood

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Purpose To compare visual field defects obtained with both multifocal visual evoked potential (mfVEP) and Humphrey visual field (HVF) techniques to topographic optic disc measurements in patients with normal tension glaucoma (NTG) and high tension glaucoma (HTG). Methods We studied 32 patients with NTG and 32 with HTG. All patients had reliable 24-2 HVFs with a mean deviation of -10 dB or better, a glaucomatous optic disc and an abnormal HVF in at least 1 eye. Multifocal VEPs were obtained from each eye and probability plots created. The mfVEP and HVF probability plots were divided into a central 10-degree radius and an outer arcuate subfield in both superior and inferior hemifields. Cluster analyses and counts of abnormal points were performed in each subfield. Optic disc images were obtained with the Heidelberg Retina Tomograph III. Eleven stereometric parameters were calculated. Moorfields regression analysis and the glaucoma probability score were performed. Results There were no significant differences in mean deviation and pattern standard deviation values between NTG and HTG eyes. However, NTG eyes had a higher percentage of abnormal test points and clusters of abnormal points in the central subfields on both mfVEP and HVF than HTG eyes. For Heidelberg Retina Tomograph III, there were no significant differences in the 11 stereometric parameters or in the Moorfields regression analysis and glaucoma probability score analyses of the optic disc images. Conclusions The visual field data suggest more localized and central defects for NTG than HTG.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalJournal of Glaucoma
Issue number3
StatePublished - 2010
Externally publishedYes


  • Heidelberg retina tomograph
  • Multifocal visual evoked potential
  • Normal tension glaucoma
  • Visual fields


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