Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay

Samuel W. Needleman; Yasuhito Yuasa; Shiv Srivastava; Stuart A. Aaronson

doi:10.1126/science.6623066

Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay

Samuel W. Needleman, Yasuhito Yuasa, Shiv Srivastava, Stuart A. Aaronson

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes.

Original language	English
Pages (from-to)	173-175
Number of pages	3
Journal	Science
Volume	222
Issue number	4620
DOIs	https://doi.org/10.1126/science.6623066
State	Published - 1983
Externally published	Yes

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title = "Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay",

abstract = "Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes.",

author = "Needleman, \{Samuel W.\} and Yasuhito Yuasa and Shiv Srivastava and Aaronson, \{Stuart A.\}",

year = "1983",

doi = "10.1126/science.6623066",

language = "English",

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pages = "173--175",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay

AU - Needleman, Samuel W.

AU - Yuasa, Yasuhito

AU - Srivastava, Shiv

AU - Aaronson, Stuart A.

PY - 1983

Y1 - 1983

N2 - Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes.

AB - Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes.

UR - https://www.scopus.com/pages/publications/0020591840

U2 - 10.1126/science.6623066

DO - 10.1126/science.6623066

M3 - Article

C2 - 6623066

AN - SCOPUS:0020591840

SN - 0036-8075

VL - 222

SP - 173

EP - 175

JO - Science

JF - Science

IS - 4620

ER -

Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay

Abstract

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