TY - JOUR
T1 - Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia
AU - Foland-Ross, Lara C.
AU - Bookheimer, Susan Y.
AU - Lieberman, Matthew D.
AU - Sugar, Catherine A.
AU - Townsend, Jennifer D.
AU - Fischer, Jeffrey
AU - Torrisi, Salvatore
AU - Penfold, Conor
AU - Madsen, Sarah K.
AU - Thompson, Paul M.
AU - Altshuler, Lori L.
N1 - Funding Information:
This work was supported by grants from the National Institute of Mental Health ( MH078556 to LCFR, and MH075944 and MH01848 to LLA). Additional support for algorithm development was provided by the National Institute on Aging (NIA) , the National Institute of Biomedical Imaging and Bioengineering (NIBIB) , and the National Center for Research Resources (NCRR; AG016570 , EB01651 , RR019771 to PT). For their generous support, the authors also thank the National Association for Research on Schizophrenia and Affective Disorders (NARSAD) , Brain Mapping Medical Research Organization , Brain Mapping Support Foundation , Pierson-Lovelace Foundation , The Ahmanson Foundation , William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation , Tamkin Foundation , Jennifer Jones-Simon Foundation , Capital Group Companies Charitable Foundation , Robson Family and Northstar Fund . The project was also supported by grant numbers RR12169 , RR13642 and RR00865 from the NCRR. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH.
PY - 2012/1/2
Y1 - 2012/1/2
N2 - Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performance of an affective faces task. Whether this pattern of dysfunction persists during euthymia is unclear. Using functional magnetic resonance imaging (fMRI), 24 euthymic bipolar and 26 demographically matched healthy control subjects were scanned while performing an affective task paradigm involving the matching and labeling of emotional facial expressions. Neuroimaging results showed that, while amygdala activation did not differ significantly between groups, euthymic patients showed a significant decrease in activation of the right vlPFC (BA47) compared to healthy controls during emotion labeling. Additionally, significant decreases in activation of the right insula, putamen, thalamus and lingual gyrus were observed in euthymic bipolar relative to healthy control subjects during the emotion labeling condition. These data, taken in context with prior studies of bipolar mania using the same emotion recognition task, could suggest that amygdala dysfunction may be a state-related abnormality in bipolar disorder, whereas vlPFC dysfunction may represent a trait-related abnormality of the illness. Characterizing these patterns of activation is likely to help in understanding the neural changes related to the different mood states in bipolar disorder, as well as changes that represent more sustained abnormalities. Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest.
AB - Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performance of an affective faces task. Whether this pattern of dysfunction persists during euthymia is unclear. Using functional magnetic resonance imaging (fMRI), 24 euthymic bipolar and 26 demographically matched healthy control subjects were scanned while performing an affective task paradigm involving the matching and labeling of emotional facial expressions. Neuroimaging results showed that, while amygdala activation did not differ significantly between groups, euthymic patients showed a significant decrease in activation of the right vlPFC (BA47) compared to healthy controls during emotion labeling. Additionally, significant decreases in activation of the right insula, putamen, thalamus and lingual gyrus were observed in euthymic bipolar relative to healthy control subjects during the emotion labeling condition. These data, taken in context with prior studies of bipolar mania using the same emotion recognition task, could suggest that amygdala dysfunction may be a state-related abnormality in bipolar disorder, whereas vlPFC dysfunction may represent a trait-related abnormality of the illness. Characterizing these patterns of activation is likely to help in understanding the neural changes related to the different mood states in bipolar disorder, as well as changes that represent more sustained abnormalities. Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest.
KW - Amygdala
KW - Bipolar disorder
KW - Emotion
KW - Prefrontal cortex
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=80054120041&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2011.07.054
DO - 10.1016/j.neuroimage.2011.07.054
M3 - Article
C2 - 21854858
AN - SCOPUS:80054120041
SN - 1053-8119
VL - 59
SP - 738
EP - 744
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -