TY - JOUR
T1 - Noradrenergic modulation of stress resilience
AU - Zhai, Xiaojing
AU - Zhou, Dongyu
AU - Han, Yi
AU - Han, Ming Hu
AU - Zhang, Hongxing
N1 - Funding Information:
The present study was supported by the National Key Research and Development Program of China ( 2021ZD0202900 and 2021ZD0203100 ), National Natural Science Foundation of China ( 31970937 and 82271255 ), Natural Science Foundation of Jiangsu Province ( BK20190047 ), Jiangsu Province Innovative and Entrepreneurial Team Program, Shenzhen Science and Technology ( JCYJ20220818101600001 ), and the Postgraduate Research and Practice Innovation Program of Jiangsu Province ( KYCX22_2918 and _2932 ).
Publisher Copyright:
© 2022 The Authors
PY - 2023/1
Y1 - 2023/1
N2 - Resilience represents an active adaption process in the face of adversity, trauma, tragedy, threats, or significant sources of stress. Investigations of neurobiological mechanisms of resilience opens an innovative direction for preclinical research and drug development for various stress-related disorders. The locus coeruleus norepinephrine system has been implicated in mediating stress susceptibility versus resilience. It has attracted increasing attention over the past decades with the revolution of modern neuroscience technologies. In this review article, we first briefly go over resilience-related concepts and introduce rodent paradigms for segregation of susceptibility and resilience, then highlight recent literature that identifies the neuronal and molecular substrates of active resilience in the locus coeruleus, and discuss possible future directions for resilience investigations.
AB - Resilience represents an active adaption process in the face of adversity, trauma, tragedy, threats, or significant sources of stress. Investigations of neurobiological mechanisms of resilience opens an innovative direction for preclinical research and drug development for various stress-related disorders. The locus coeruleus norepinephrine system has been implicated in mediating stress susceptibility versus resilience. It has attracted increasing attention over the past decades with the revolution of modern neuroscience technologies. In this review article, we first briefly go over resilience-related concepts and introduce rodent paradigms for segregation of susceptibility and resilience, then highlight recent literature that identifies the neuronal and molecular substrates of active resilience in the locus coeruleus, and discuss possible future directions for resilience investigations.
KW - Antidepressant
KW - DK-AH269 (PubChem CID: 132989)
KW - Fluoxetine (PubChem CID: 3386)
KW - Idazoxan (PubChem CID: 54459)
KW - Locus coeruleus
KW - Molecular mechanisms
KW - Neural circuit
KW - Norepinephrine
KW - Resilience
KW - Retigabine (PubChem CID: 121892)
KW - Spravato (PubChem CID: 182137)
KW - ZD7288 (PubChem CID: 123983)
KW - Zulresso (PubChem CID: 92786)
UR - http://www.scopus.com/inward/record.url?scp=85145601524&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2022.106598
DO - 10.1016/j.phrs.2022.106598
M3 - Review article
C2 - 36481260
AN - SCOPUS:85145601524
SN - 1043-6618
VL - 187
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 106598
ER -