TY - JOUR
T1 - Noradrenergic mechanisms in ADHD children with and without reading disabilities
T2 - A replication and extension
AU - Halperin, Jeffrey M.
AU - Newcorn, Jeffrey H.
AU - Koda, Vivian H.
AU - Pick, Lawrence
AU - McKay, Kathleen E.
AU - Knott, Peter
N1 - Funding Information:
Acapudjuly I. 1997. Dr. Halperin is with th« Psychology Department, Quam Coll~g~ ofth« City UniversityofNeio York. and the Psychiatry Department, Mount Sinai School of Medicinr. Drs. Neiocorn, McKay. and Knott are with thr Psychiatry Department, Mount Sinai School ofMedicine. Ms. Koda and M r. Pick are with th« N~uropjychology Doctoral Programofth~ City University of Neu:York. This research was supported by NIMH grant I ROI MH46448. Th~ William T. Grant Foundation'sFaculty Scholar s Award Program. and grant 5 M O I RR00071 to th« Mount Sinai Genera] Clinical Rm arch Center.from th~ NationalCenterfOrResearchRaources.NIH. TheauthorsthankDO,lIIaD. Holland. who p~rform~d th~ HPLC analyses ofMHPG and H VA; and Kurt Schulz.fOrdrawing the schematic and providing h~lpjUl comments. Reprin: r~qu~sts to Dr. Halperin, Psychology Department, Quam Collrg~. 65-30 Kissena Blvd, Flushing. N Y 11367.
PY - 1997/12
Y1 - 1997/12
N2 - Objective: To examine noradrenergic (NA) function in children with attention-deficit hyperactivity disorder (ADHD) by replicating and expanding upon a previous finding that ADHD children with and without reading disabilities (RD) differ in plasma levels of the NA metabolite 3-methoxy-4- hydroxyphenylglycol (MHPG). Method: Plasma levels of MHPG were compared in ADHD children who were subdivided on the basis of the presence or absence of RD. Subsequently, this replication sample was combined with a previously studied sample to further explore the relationship between plasma MHPG levels and measures of cognitive function in children with ADHD. Results: Plasma revels of MHPG were significantly lower in ADHD children without RD, compared with those with RD, replicating a previously published finding. Analyses in the combined sample indicated that, among children with ADHD, plasma MHPG levels were inversely associated with measures of academic achievement and verbal processing, but not parent or teacher ratings of behavior or continuous performance test measures of attention and impulsivity. Conclusions: These data indicate that children with ADHD are not homogeneous with regard to NA function and that neurochemical variation is closely associated with differences in clinical characteristics of the children.
AB - Objective: To examine noradrenergic (NA) function in children with attention-deficit hyperactivity disorder (ADHD) by replicating and expanding upon a previous finding that ADHD children with and without reading disabilities (RD) differ in plasma levels of the NA metabolite 3-methoxy-4- hydroxyphenylglycol (MHPG). Method: Plasma levels of MHPG were compared in ADHD children who were subdivided on the basis of the presence or absence of RD. Subsequently, this replication sample was combined with a previously studied sample to further explore the relationship between plasma MHPG levels and measures of cognitive function in children with ADHD. Results: Plasma revels of MHPG were significantly lower in ADHD children without RD, compared with those with RD, replicating a previously published finding. Analyses in the combined sample indicated that, among children with ADHD, plasma MHPG levels were inversely associated with measures of academic achievement and verbal processing, but not parent or teacher ratings of behavior or continuous performance test measures of attention and impulsivity. Conclusions: These data indicate that children with ADHD are not homogeneous with regard to NA function and that neurochemical variation is closely associated with differences in clinical characteristics of the children.
KW - 3-melhoxy-4-hydroxyphenylglycol
KW - Attention-deficit hyperectivity disorder
KW - Children
KW - Norepinephrine
KW - Reading disability
UR - https://www.scopus.com/pages/publications/0030728778
U2 - 10.1097/00004583-199712000-00017
DO - 10.1097/00004583-199712000-00017
M3 - Article
C2 - 9401330
AN - SCOPUS:0030728778
SN - 0890-8567
VL - 36
SP - 1688
EP - 1697
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 12
ER -