TY - CHAP
T1 - Nontumor Prognostic Factors in Hepatocellular Carcinoma
AU - Goossens, Nicolas
AU - Labgaa, Ismail
AU - Villanueva, Augusto
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2016.
PY - 2016
Y1 - 2016
N2 - The risk of developing hepatocellular carcinoma (HCC) and its prognosis once developed varies across different patients. Since most HCC arise on a previously damaged liver, non-HCC factors have been shown to significantly impact patient outcome. Clinical-and pathology-based risk and prognostic predictors have been widely studied, but their performance is partially limited, especially in subjects not in the extreme of the risk profiles. Molecular prognostic indicators are expected to refine the predictions in patients with HCC although no molecular prognostic predictor has been yet formally recommended in clinical practice guidelines. However, predicted changes in the epidemiology of HCC and the rapid evolution of genomic technologies indicate that molecular-based predictors may soon be implemented in routine clinical conditions.
AB - The risk of developing hepatocellular carcinoma (HCC) and its prognosis once developed varies across different patients. Since most HCC arise on a previously damaged liver, non-HCC factors have been shown to significantly impact patient outcome. Clinical-and pathology-based risk and prognostic predictors have been widely studied, but their performance is partially limited, especially in subjects not in the extreme of the risk profiles. Molecular prognostic indicators are expected to refine the predictions in patients with HCC although no molecular prognostic predictor has been yet formally recommended in clinical practice guidelines. However, predicted changes in the epidemiology of HCC and the rapid evolution of genomic technologies indicate that molecular-based predictors may soon be implemented in routine clinical conditions.
KW - Mica Gene
KW - Nontumoral Liver Tissue
KW - Single Nucleotide Polymorphism
KW - Specific Radiological Feature
KW - Sustained Virological Response
UR - https://www.scopus.com/pages/publications/105033194319
U2 - 10.1007/978-3-319-34214-6_8
DO - 10.1007/978-3-319-34214-6_8
M3 - Chapter
AN - SCOPUS:105033194319
T3 - Current Clinical Oncology
SP - 139
EP - 147
BT - Current Clinical Oncology
PB - Springer International Publishing
ER -