Non‐respondents in a Post‐myocardial Infarction Trial: Characteristics and Reasons for Refusal


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ABSTRACT We surveyed the 270 survivors of acute myocardial infarction who refused to participate in the Warfarin Re‐Infarction Study (WARIS). Information on medical variables were derived from registration forms completed by hospital staff upon discharge, whereas data on a variety of health conditions and reasons for refusal were gathered by mailed questionnaires, 178 (66%) of which were returned. Some disparities were found when comparing non‐respondents and participants, the former showing more potential bad risk factors. The diversities between participants and non‐respondents are of yet unknown prognostic importance. However, the presence of such differences imply that information on characteristics of non‐respondents in clinical trials is desirable in terms of generalizability of the trial results. Reasons stated for non‐participation reflect poor motivation, low mobility and saturation with focusing on disease. A slight co‐variation between social status and reasons for refusal was noted. 1988 Association for the Publication of the Journal of Internal Medicine

Original languageEnglish
Pages (from-to)537-542
Number of pages6
JournalActa Medica Scandinavica
Issue number6
StatePublished - 1988
Externally publishedYes


  • clinical trials
  • generalizability
  • non‐respondents


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