TY - JOUR
T1 - Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas
AU - Ohno, Shinsuke
AU - Babonits, Magda
AU - Wiener, Francis
AU - Spira, Jack
AU - Klein, George
AU - Potter, Michael
N1 - Funding Information:
We wish to express our sincere thanks to Mrs. Agneta Manneborg Sandlund and Mrs. Judy Wax for their excellent technical assistance. This investigation was supported by grants awarded by the National Cancer Institute. DHEW and the Swedish Cancer Society. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 16 U.S.C. Section 1734 solely to indicate this fact.
PY - 1979/12
Y1 - 1979/12
N2 - The karyotypes of pristane-induced mouse plasmacytomas were studied by G banding. Only primary tumors or early passage generations were analyzed. In contrast to murine T cell leukemias that showed a regular trisomy of chromosome 15, all plasmacytomas showed a consistent translocation of the distal part of chromosome 15 to either chromosome 6 [rcpT(6; 15)] or 12 [T(12; 15)]. The specific breakpoints were at 6C, 15D3/E or D2/3 and 12F2. Early passage generations often showed a mixed population with two different translocations, suggesting polyclonal origin. Considered together with the known karyotypic features of murine and human lymphomas, these findings support the theory that the nonrandom chromosomal changes in lymphoproliferative malignancies are associated with the type of the target cell, rather than with the etiological agent. Moreover, the involvement of the chromosomes known to carry the heavy chain (12) and the light chain (6) determinants, respectively, raises the question of whether the translocations may be related to the DNA level rearrangements known to occur during the differentiation of normal plasma cells.
AB - The karyotypes of pristane-induced mouse plasmacytomas were studied by G banding. Only primary tumors or early passage generations were analyzed. In contrast to murine T cell leukemias that showed a regular trisomy of chromosome 15, all plasmacytomas showed a consistent translocation of the distal part of chromosome 15 to either chromosome 6 [rcpT(6; 15)] or 12 [T(12; 15)]. The specific breakpoints were at 6C, 15D3/E or D2/3 and 12F2. Early passage generations often showed a mixed population with two different translocations, suggesting polyclonal origin. Considered together with the known karyotypic features of murine and human lymphomas, these findings support the theory that the nonrandom chromosomal changes in lymphoproliferative malignancies are associated with the type of the target cell, rather than with the etiological agent. Moreover, the involvement of the chromosomes known to carry the heavy chain (12) and the light chain (6) determinants, respectively, raises the question of whether the translocations may be related to the DNA level rearrangements known to occur during the differentiation of normal plasma cells.
UR - http://www.scopus.com/inward/record.url?scp=0018576053&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(79)90212-5
DO - 10.1016/0092-8674(79)90212-5
M3 - Article
C2 - 519762
AN - SCOPUS:0018576053
SN - 0092-8674
VL - 18
SP - 1001
EP - 1007
JO - Cell
JF - Cell
IS - 4
ER -