Nonoperative management of discogenic back pain: A systematic review

Young Lu, Javier Z. Guzman, Devina Purmessur, James C. Iatridis, Andrew C. Hecht, Sheeraz A. Qureshi, Samuel K. Cho

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Study Design.: Systematic review of the literature. Objective.: A systematic evaluation of the literature was performed to investigate current nonoperative management of the treatment of discogenic low back pain. Summary of Background Data.: Back pain is a major health care concern with up to 39% being discogenic in origin according to one study. Nonoperative therapy is likely to be the initial treatment strategy for discogenic low back pain. Methods.: PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched for clinical studies evaluating nonoperative methods of treating discogenic back pain that were published between 2000 and 2012. Only prospective randomized controlled studies that compared a nonsurgical intervention with sham or placebo therapy were included. After removal of duplicate citations, a total of 226 articles were initially identified from the search terms. From these, we identified 11 randomized controlled trials (RCTs) from which data analysis was performed. Results.: The 11 RCTs investigated traction therapy, injections, and ablative techniques. Results from 5 RCTs investigating methylene blue injection, steroid injection, ramus communicans ablation, intradiscal electrothermal therapy, and biacuplasty favored intervention over sham therapy. However, results from the study on methylene blue injections have not been replicated in other RCTs. Evaluation of the selection criteria used in the studies on ramus communicans ablation and intradiscal biacuplasty and a stratified analysis of results from the RCTs on intradiscal electrothermal therapy casts doubt on whether the conclusions from these RCTs can be applied to the general patient population with discogenic pain. Conclusion.: There are few high-quality studies evaluating nonoperative treatments for reducing discogenic low back pain. Although conclusions from several studies favor intervention over sham, it is unclear whether these interventions confer stable long-term benefit. There is some promise in newer modalities such as biacuplasty; however, more inclusive studies need to be performed.

Original languageEnglish
Pages (from-to)1314-1324
Number of pages11
Issue number16
StatePublished - 15 Jul 2014


  • ablative therapy
  • analgesia
  • biacuplasty
  • discogenic
  • electrothermal therapy
  • intradiscal
  • low back pain
  • methylene blue
  • nociceptive
  • nonoperative
  • percutaneous intradiscal radio frequency coagulation
  • provocative discography
  • ramus communicans
  • steroid injection


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