Noninvasive monitoring of serial changes in pulmonary vascular resistance and acute vasodilator testing using cardiac magnetic resonance

Ana García-Álvarez, Leticia Fernández-Friera, José Manuel García-Ruiz, Mario Nuño-Ayala, Daniel Pereda, Rodrigo Fernández-Jiménez, Gabriela Guzmán, Damián Sanchez-Quintana, Angel Alberich-Bayarri, David Pastor-Escuredo, David Sanz-Rosa, Jaime García-Prieto, Jesús G. Gonzalez-Mirelis, Gonzalo Pizarro, Luis Jesús Jimenez-Borreguero, Valentín Fuster, Javier Sanz, Borja Ibáñez

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Objectives The study sought to evaluate the ability of cardiac magnetic resonance (CMR) to monitor acute and long-term changes in pulmonary vascular resistance (PVR) noninvasively. Background PVR monitoring during the follow-up of patients with pulmonary hypertension (PH) and the response to vasodilator testing require invasive right heart catheterization. Methods An experimental study in pigs was designed to evaluate the ability of CMR to monitor: 1) an acute increase in PVR generated by acute pulmonary embolization (n = 10); 2) serial changes in PVR in chronic PH (n = 22); and 3) changes in PVR during vasodilator testing in chronic PH (n = 10). CMR studies were performed with simultaneous hemodynamic assessment using a CMR-compatible Swan-Ganz catheter. Average flow velocity in the main pulmonary artery (PA) was quantified with phase contrast imaging. Pearson correlation and mixed model analysis were used to correlate changes in PVR with changes in CMR-quantified PA velocity. Additionally, PVR was estimated from CMR data (PA velocity and right ventricular ejection fraction) using a formula previously validated. Results Changes in PA velocity strongly and inversely correlated with acute increases in PVR induced by pulmonary embolization (r = -0.92), serial PVR fluctuations in chronic PH (r = -0.89), and acute reductions during vasodilator testing (r = -0.89, p ≤ 0.01 for all). CMR-estimated PVR showed adequate agreement with invasive PVR (mean bias -1.1 Wood units,; 95% confidence interval: -5.9 to 3.7) and changes in both indices correlated strongly (r = 0.86, p < 0.01). Conclusions CMR allows for noninvasive monitoring of acute and chronic changes in PVR in PH. This capability may be valuable in the evaluation and follow-up of patients with PH.

Original languageEnglish
Pages (from-to)1621-1631
Number of pages11
JournalJournal of the American College of Cardiology
Issue number17
StatePublished - 22 Oct 2013


  • magnetic resonance
  • monitoring
  • pulmonary hypertension
  • pulmonary vascular resistance
  • vasodilator testing


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