Noninfectious risks of transfusion

Jeffrey S. Jhang, Suzanne Arinsburg

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The goal of blood component therapy is to achieve the desired effect without adverse outcomes. The desired effect may be to increase oxygen carrying capacity, correct coagulation factor deficiencies, or provide cellular components. However, adverse outcomes due to errors, accidents, or transfusion reactions cannot be completely avoided. Despite risk mitigation, the rate of transfusion reactions is 2.4 reactions per 1000 units transfused. Transfusion reactions can be just an annoyance (e.g., urticarial), but more severe reactions can be life threatening (e.g., anaphylaxis). The Transfusion Medicine specialist must be able to recognize, treat, and prevent future reactions by providing a comprehensive consultation for all reported reactions. The blood banking community has been very successful at reducing the risk of transfusion transmitted infections and is continually improving transfusion safety and risk mitigation. The purpose of this chapter on noninfectious risks of transfusion is to enhance the ability of the user to recognize, treat, and prevent these transfusion reactions.

Original languageEnglish
Title of host publicationTransfusion Medicine, Apheresis, and Hemostasis
Subtitle of host publicationReview Questions and Case Studies
Number of pages28
ISBN (Electronic)9780128039991
ISBN (Print)9780128040300
StatePublished - 20 Sep 2017


  • Anaphylaxis
  • Blood bank
  • Blood component therapy
  • Coagulation
  • Risk mitigation
  • Transfusion reactions
  • Transfusion transmitted infections


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