Non-T, non-B acute lymphoblastic leukemia (L3) with t(8;22) and two 14q+ chromosomes

R. S.K. Chaganti, Suresh C. Jhanwar, Zalmen Arlin, Benjamin Koziner, Appaji Ambati, Michael Andreeff, Bayard D. Clarkson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A patient with L3 leukemia is reported whose leukemic cells were characterized cytogenetically by a duplication of the long arm segment 1q25→q42, trisomy for chromosome 7, t(8;22)(q24;q11), and two 14q+ chromosomes. Immunologic marker analysis revealed the leukemic cells to be of the non-T, non-B ("null") type. This observation, when considered in conjunction with a previous report of heterogeneity in cell lineages of L3 leukemias, raises the possibility of some lymphoid neoplasms arising in stem cells.

Original languageEnglish
Pages (from-to)95-103
Number of pages9
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - Sep 1983
Externally publishedYes


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