Non-permissive SARS-CoV-2 infection in human neurospheres

Carolina da S.G. Pedrosa, Livia Goto-Silva, Jairo R. Temerozo, Leticia R.Q. Souza, Gabriela Vitória, Isis M. Ornelas, Karina Karmirian, Mayara A. Mendes, Ismael C. Gomes, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Vinicius Cardoso Soares, Suelen da Silva Gomes Dias, José A. Salerno, Teresa Puig-Pijuan, Julia T. Oliveira, Luiz G.H.S. Aragão, Thayana C.Q. Torquato, Carla Veríssimo, Diogo BiagiEstela M. Cruvinel, Rafael Dariolli, Daniel R. Furtado, Helena L. Borges, Patrícia T. Bozza, Stevens Rehen, Thiago Moreno L. Souza, Marília Zaluar P. Guimarães

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.

Original languageEnglish
Article number102436
JournalStem Cell Research
Volume54
DOIs
StatePublished - Jul 2021

Keywords

  • Brain
  • Neurospheres
  • New coronavirus
  • SARS-CoV-2
  • iPS

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