Non-ige-mediated gastrointestinal food allergies in children: An update

Roxane Labrosse, François Graham, Jean Christoph Caubet

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of variable severity, affecting the gastrointestinal tract in response to specific dietary antigens. The diagnosis of non-IgE-GI-FA is made clinically, and relies on a constellation of typical symptoms that improve upon removal of the culprit food. When possible, food reintroduction should be attempted, with the documentation of symptoms relapse to establish a conclusive diagnosis. Management includes dietary avoidance, nutritional counselling, and supportive measures in the case of accidental exposure. The prognosis is generally favorable, with the majority of cases resolved before school age. Serial follow-up to establish whether the acquisition of tolerance has occurred is therefore essential in order to avoid unnecessary food restriction and potential consequent nutritional deficiencies. The purpose of this review is to delineate the distinctive clinical features of non-IgE-mediated food allergies presenting with gastrointestinal symptomatology, to summarize our current understanding of the pathogenesis driving these diseases, to discuss recent findings, and to address currents gaps in the knowledge, to guide future management opportunities.

Original languageEnglish
Article number2086
Pages (from-to)1-28
Number of pages28
Issue number7
StatePublished - Jul 2020
Externally publishedYes


  • FPE
  • Food allergy
  • Gastrointestinal reactions
  • Non-IgE-mediated
  • Nutrition
  • Pediatrics


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