Non-IgE-mediated gastrointestinal food allergies in children

Jean Christoph Caubet, Hania Szajewska, Raanan Shamir, Anna Nowak-Węgrzyn

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


Non-IgE-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) including food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE), and food protein-induced allergic proctocolitis (FPIAP) are relatively uncommon in infants and young children, but are likely under-diagnosed. Non-IgE-GI-FA have a favorable prognosis, with majority resolving by age 3–5 years. Diagnosis relies on the recognition of symptoms pattern in FPIAP and FPIES and biopsy in FPE. Further studies are needed for a better understanding of the pathomechanism, which will lead eventually to the development of diagnostic tests and treatments. Limited evidence supports the role of food allergens in subsets of constipation, gastroesophageal reflux disease, irritable bowel syndrome, and colic. The immunologic pathomechanism is not fully understood and empiric prolonged avoidance of food allergens should be limited to minimize nutrient deficiency and feeding disorders/food aversions in infants.

Original languageEnglish
Pages (from-to)6-17
Number of pages12
JournalPediatric Allergy and Immunology
Issue number1
StatePublished - 1 Feb 2017


  • allergic proctocolitis
  • celiac disease
  • constipation
  • fermentable oligosaccharides, disaccharides, monosaccharides and polyols
  • food allergy
  • food protein-induced allergic proctocolitis
  • food protein-induced enterocolitis syndrome
  • food protein-induced enterocolitis syndrome
  • food protein-induced enteropathy
  • food protein-induced enteropathy
  • gastroesophageal reflux
  • gastroesophageal reflux
  • gastroesophageal reflux disease
  • gastroesophageal reflux disease
  • gastrointestinal food allergy
  • irritable bowel syndrome


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