Non-esophageal eosinophilic gastrointestinal disorders

Xiuxu Chen, Xianzhong Ding, Huaibin M. Ko

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Eosinophilic gastrointestinal disorders (EGIDs) refer to a rare group of chronic immune-mediated diseases of the tubular gastrointestinal tract, characterized clinically by gastrointestinal dysfunction and symptoms, and histologically by eosinophil-predominant immune response with unknown etiology. They include eosinophilic esophagitis (EoE), gastritis (EoG), enteritis (EoN) and colitis (EoC) based on sites involved according the latest International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature (2022 ICR-EGID Nomenclature). EoE is the most well-studied entity of EGIDs with established diagnostic criteria, 3 endotypes (OMEGA study), histology scoring system (EoEHSS), randomized clinical trials (SOFEED study), and non-IgE-mediated hypersensitive reaction as its presumed pathogenesis. Non-esophageal gastrointestinal disorders (Non-EoE EGIDs), although reported more than four decades earlier than EoE, are however less well-understood. The rarity of these diseases, heterogeneous clinical presentations, broad differential diagnosis, and most importantly, the lack of a consensus on diagnostic criteria and clinical management have all contributed to an incomplete understanding of these diseases. This review focuses on diagnosis of Non-EoE EGIDs and discusses several challenges we face in daily practice from a pathologist perspective.

Original languageEnglish
Article number300655
JournalHuman Pathology Reports
Volume29
DOIs
StatePublished - Sep 2022
Externally publishedYes

Keywords

  • EGIDs
  • Eosinophilic colitis
  • Eosinophilic duodenitis
  • Eosinophilic gastritis
  • Eosinophilic gastroenteritis
  • Eosinophilic gastrointestinal disorders
  • Non-EoE EGIDs
  • Non-esophageal eosinophilic gastrointestinal disorders

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