Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues

Christian Münz

doi:10.1002/eji.200838849

Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues

Christian Münz

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Even though NK cells have been named for their spontaneous cytotoxicity, a large subpopulation of human NK cells primarily responds to activation with cytokine secretion and not killing. These CD56^brightCD16 NK cells are abundant in secondary lymphoid tissues, can restrict pathogens that have breached mucosal barriers, and assist Th1 polarization during immune response priming. This exciting new aspect of NK-cell biology is discussed in this viewpoint.

Original language	English
Pages (from-to)	2946-2948
Number of pages	3
Journal	European Journal of Immunology
Volume	38
Issue number	11
DOIs	https://doi.org/10.1002/eji.200838849
State	Published - 2008
Externally published	Yes

Keywords

Cytokine secretion
T-cell polarization
Tonsil

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10.1002/eji.200838849

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title = "Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues",

abstract = "Even though NK cells have been named for their spontaneous cytotoxicity, a large subpopulation of human NK cells primarily responds to activation with cytokine secretion and not killing. These CD56brightCD16 NK cells are abundant in secondary lymphoid tissues, can restrict pathogens that have breached mucosal barriers, and assist Th1 polarization during immune response priming. This exciting new aspect of NK-cell biology is discussed in this viewpoint.",

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AB - Even though NK cells have been named for their spontaneous cytotoxicity, a large subpopulation of human NK cells primarily responds to activation with cytokine secretion and not killing. These CD56brightCD16 NK cells are abundant in secondary lymphoid tissues, can restrict pathogens that have breached mucosal barriers, and assist Th1 polarization during immune response priming. This exciting new aspect of NK-cell biology is discussed in this viewpoint.

KW - Cytokine secretion

KW - T-cell polarization

KW - Tonsil

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DO - 10.1002/eji.200838849

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AN - SCOPUS:58149326956

SN - 0014-2980

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SP - 2946

EP - 2948

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 11

ER -

Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues

Abstract

Keywords

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