@article{537e5255cf4a4086baba1c9e6f981169,
title = "NON-CYTOCIDAL NATURAL VARIANTS OF HUMAN IMMUNODEFICIENCY VIRUS ISOLATED FROM AIDS PATIENTS WITH NEUROLOGICAL DISORDERS",
abstract = "To understand the mechanism of HIVmediated neuropathology five viral isolates were obtained from four AIDS cases with central nervous system manifestations as the primary involvement. The isolates were identified as HIVs by antigenic cross-reactivity and nucleic acid hybridisations to HIV-specific antibodies and DNA probes. The replication and cytopathic properties of these isolates were studied and compared with lymphadenopathy-associated virus (HIVLAV). All isolates had replication competence equivalent to LAV, but four isolates did not kill T4 (CD-4) cells. This isolation of non-cytocidal natural variants of HIV raises the possibility that in some AIDS cases the neurological disorders might be due to HIV variants that are non-cytocidal to T4 cells. The results also indicate that virus replication and cytotoxicity are not always concordant functions in HIV.",
author = "Rita Anand and Carol Reed and Susan Forlenza and Frederick Siegal and Tony Cheung and Jennifer Moore",
note = "Funding Information: assistance and to the Simon Broome Heart Research Trust, the Wellcome Foundation, and the Medical Research Council for financial assistance. G. J. S. C. holds an Oxford Nuffield Medical Research Fellowship. C. E. L. is a Wellcome Trust research scientist. We thank Miss Rachel Church for preparing the script and Dr David Pow for helping with the photography; Professor Dockray and Professor Craig for generous gifts of antisera; Dr R. B. Sim, Mr A. Day, Dr S. K. A. Law, Ms J. Parsons, Dr A. Dodds, Dr D. Williamson, Dr R. Campbell, for helpful discussions; and many colleagues-including Dr C. A. Wells, Dr 1. Buley, Dr P. Millard, Mr W. Zawalmski, Mr L. Hurman (John Radcliffe Hospital, Oxford); Dr R.I. Vanhegan (Princess Margaret{\textquoteright}s Hospital, Swindon); Dr J. K. Cruickshank (Central Middlesex Hospital); Mr N. S. G. Wood, Prof E. L. Jones, Dr D. A. Wright (Birmingham General Hospital); Mr D. 1. Buchanan, Dr J. Rivett, Dr D. A. Knight (Stoke Mandeville Hospital); Dr K. A. K. North (Royal Berkshire Hospital, Reading); and Dr M. M. Ali, (Wexham Park Hospital, Slough)--for help in obtaining post-mortem material.",
year = "1987",
month = aug,
day = "1",
doi = "10.1016/S0140-6736(87)90826-9",
language = "English",
volume = "330",
pages = "234--238",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Ltd.",
number = "8553",
}