Non-coding RNA in endothelial-to-mesenchymal transition

Melanie S. Hulshoff, Gonzalo Del Monte-Nieto, Jason Kovacic, Guido Krenning

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial maturation, but activation of the EndMT programme during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease, and cancer. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding RNAs facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding RNAs to treat fibroproliferative cardiovascular disease.

Original languageEnglish
Pages (from-to)1716-1731
Number of pages16
JournalCardiovascular Research
Issue number12
StatePublished - 1 Oct 2019


  • Cardiac development
  • Cardiovascular disease
  • Endothelial-mesenchymal transition (EndMT)
  • Non-coding RNA
  • Plasticity


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