TY - JOUR
T1 - Nodular lymphocyte predominant hodgkin lymphoma
T2 - Biology, diagnosis and treatment
AU - Goel, Anupama
AU - Fan, Wen
AU - Patel, Amit A.
AU - Devabhaktuni, Madhuri
AU - Grossbard, Michael L.
PY - 2014/8
Y1 - 2014/8
N2 - Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of classical Hodgkin lymphoma. It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30. Patients often present with early stage of disease and do not have classical B symptoms. The clinical behavior appears to mimic that of an indolent non-Hodgkin lymphoma more than that of classical Hodgkin disease. The purpose of the present report is to define the biology of NLPHL, review its clinical presentation, and summarize the available clinical data regarding treatment.
AB - Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of classical Hodgkin lymphoma. It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30. Patients often present with early stage of disease and do not have classical B symptoms. The clinical behavior appears to mimic that of an indolent non-Hodgkin lymphoma more than that of classical Hodgkin disease. The purpose of the present report is to define the biology of NLPHL, review its clinical presentation, and summarize the available clinical data regarding treatment.
KW - Hodgkin lymphoma
KW - LP cell
KW - NLPHL
KW - Popcorn cell
KW - Reed Sternberg cells
UR - http://www.scopus.com/inward/record.url?scp=84904647397&partnerID=8YFLogxK
U2 - 10.1016/j.clml.2014.01.006
DO - 10.1016/j.clml.2014.01.006
M3 - Review article
C2 - 24650975
AN - SCOPUS:84904647397
SN - 2152-2650
VL - 14
SP - 261
EP - 270
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 4
ER -