No sustained effects of an intervention to prevent excessive GWG on offspring fat and lean mass at 54 weeks: Yet a greater head circumference persists

Kathryn Whyte, Jill Johnson, Kim Kelly, Michelle Horowitz, Elizabeth M. Widen, Tatiana Toro-Ramos, Sonia Gidwani, Charles Paley, Janet Crane, Susan Lin, Barak Rosenn, John Thornton, F. Xavier Pi-Sunyer, Dympna Gallagher

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: LIFT (Lifestyle Intervention for Two) trial found that intervening in women with overweight and obesity through promoting healthy diet and physical activity to control gestational weight gain (GWG) resulted in neonates with greater weight, lean mass and head circumference and similar fat mass at birth. Whether these neonate outcomes are sustained at 1-year was the focus of this investigation. Methods: Measures included body composition by PEA POD air displacement plethysmography (ADP) and Echo Infant quantitative magnetic resonance (QMR) and head circumference at birth (n = 169), 14 (n = 136) and 54 weeks (n = 137). Differences in fat and lean mass between lifestyle intervention (LI) and Usual care (UC) groups were examined using ANCOVA adjusting for maternal age and BMI, GWG, offspring sex and age. Results: Compared to UC, LI infants had similar weight (112 ± 131 g; P =.40), fat mass (14 ± 80 g; P =.86), lean mass (100 ± 63 g; P =.12) at 14 weeks and similar weight (168 ± 183 g; P =.36), fat mass (148 ± 124 g; P =.24), lean mass (117 ± 92 g; P =.21) at 54 weeks. Head circumference was greater in LI at 54 weeks (0.46 ± 2.1 cm P =.03). Conclusions: Greater lean mass observed at birth in LI offspring was not sustained at 14 and 54 weeks, whereas the greater head circumference in LI offspring persisted at 54 weeks.

Original languageEnglish
Article numbere12767
JournalPediatric obesity
Volume16
Issue number7
DOIs
StatePublished - Jul 2021
Externally publishedYes

Keywords

  • fat mass
  • infant body composition
  • prenatal intervention

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