@article{bdb0e634e47f4882af4a31fe56f8e09f,
title = "No sustained effects of an intervention to prevent excessive GWG on offspring fat and lean mass at 54 weeks: Yet a greater head circumference persists",
abstract = "Background: LIFT (Lifestyle Intervention for Two) trial found that intervening in women with overweight and obesity through promoting healthy diet and physical activity to control gestational weight gain (GWG) resulted in neonates with greater weight, lean mass and head circumference and similar fat mass at birth. Whether these neonate outcomes are sustained at 1-year was the focus of this investigation. Methods: Measures included body composition by PEA POD air displacement plethysmography (ADP) and Echo Infant quantitative magnetic resonance (QMR) and head circumference at birth (n = 169), 14 (n = 136) and 54 weeks (n = 137). Differences in fat and lean mass between lifestyle intervention (LI) and Usual care (UC) groups were examined using ANCOVA adjusting for maternal age and BMI, GWG, offspring sex and age. Results: Compared to UC, LI infants had similar weight (112 ± 131 g; P =.40), fat mass (14 ± 80 g; P =.86), lean mass (100 ± 63 g; P =.12) at 14 weeks and similar weight (168 ± 183 g; P =.36), fat mass (148 ± 124 g; P =.24), lean mass (117 ± 92 g; P =.21) at 54 weeks. Head circumference was greater in LI at 54 weeks (0.46 ± 2.1 cm P =.03). Conclusions: Greater lean mass observed at birth in LI offspring was not sustained at 14 and 54 weeks, whereas the greater head circumference in LI offspring persisted at 54 weeks.",
keywords = "fat mass, infant body composition, prenatal intervention",
author = "Kathryn Whyte and Jill Johnson and Kim Kelly and Michelle Horowitz and Widen, {Elizabeth M.} and Tatiana Toro-Ramos and Sonia Gidwani and Charles Paley and Janet Crane and Susan Lin and Barak Rosenn and John Thornton and Pi-Sunyer, {F. Xavier} and Dympna Gallagher",
note = "Funding Information: Research reported in this publication was supported by the National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, U01 DK094418, U01 DK094463, U01 DK094416, 5U01 DK094466 [RCU]), the National Heart, Lung, and Blood Institute (NHLBI, U01 HL114344, U01 HL114377), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, U01 HD072834), the National Center for Complementary and Integrative Health (NCCIH), the NIH Office of Research in Women's Health (ORWH), the Office of Behavioral and Social Science Research (OBSSR), the NIH Office of Disease Prevention (ODP), the Indian Health Service, the Intramural Research Program of the NIDDK, and the Office of the Director, National Institutes of Health (OD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank the LIFE‐Moms consortium members for their contributions to the development and oversight of the common measures and procedures shared across the trials. Funding Information: Division of Intramural Research, National Institute of Diabetes and Digestive and Kidney Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Grant/Award Number: U01 HD072834; Indian Health Service; National Center for Complementary and Integrative Health; National Heart, Lung, and Blood Institute, Grant/Award Numbers: U01 HL114344, U01 HL114377; National Institute of Diabetes and Digestive and Kidney Diseases, Grant/Award Numbers: 5U01 DK094466, U01 DK094416, U01 DK094418, U01 DK094463; National Institutes of Health, Grant/Award Numbers: K99/R00HD086304, P30‐DK026687, T32‐DK007559, U01‐DK094463, U01‐DK094463‐Supplement; NIH Office of Disease Prevention; NIH Office of the Director; Office of Behavioral and Social Sciences Research; Office of Research on Women's Health Funding information Funding Information: National Institutes of Health Grants U01-DK094463; U01-DK094463-Supplement (Supplement to promote diversity, T. Toro-Ramos, PhD); P30-DK026687; T32-DK007559 (Whyte, Toro-Ramos, Widen); T32DK091227 (Widen); K99/R00HD086304 to E. Widen. Research reported in this publication was supported by the National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, U01 DK094418, U01 DK094463, U01 DK094416, 5U01 DK094466 [RCU]), the National Heart, Lung, and Blood Institute (NHLBI, U01 HL114344, U01 HL114377), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, U01 HD072834), the National Center for Complementary and Integrative Health (NCCIH), the NIH Office of Research in Women's Health (ORWH), the Office of Behavioral and Social Science Research (OBSSR), the NIH Office of Disease Prevention (ODP), the Indian Health Service, the Intramural Research Program of the NIDDK, and the Office of the Director, National Institutes of Health (OD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank the LIFE-Moms consortium members for their contributions to the development and oversight of the common measures and procedures shared across the trials. Publisher Copyright: {\textcopyright} 2021 World Obesity Federation",
year = "2021",
month = jul,
doi = "10.1111/ijpo.12767",
language = "English",
volume = "16",
journal = "Pediatric obesity",
issn = "2047-6302",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",
number = "7",
}