No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder

Gijsje Snijders; Maarten J. Titulaer; Veerle Bergink; Anna E. Bastiaansen; Marco W.J. Schreurs; Roel A. Ophoff; Marco P. Boks; René S. Kahn; Lot D. de Witte

doi:10.1016/j.psychres.2017.10.043

No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder

Gijsje Snijders, Maarten J. Titulaer, Veerle Bergink, Anna E. Bastiaansen, Marco W.J. Schreurs, Roel A. Ophoff, Marco P. Boks, René S. Kahn, Lot D. de Witte

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.

Original language	English
Pages (from-to)	460-462
Number of pages	3
Journal	Psychiatry Research
Volume	259
DOIs	https://doi.org/10.1016/j.psychres.2017.10.043
State	Published - Jan 2018
Externally published	Yes

Keywords

Antibodies
Autoimmune
Bipolar disorder
Encephalitis
Immunology
Mania

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10.1016/j.psychres.2017.10.043

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title = "No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder",

abstract = "A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.",

keywords = "Antibodies, Autoimmune, Bipolar disorder, Encephalitis, Immunology, Mania",

author = "Gijsje Snijders and Titulaer, {Maarten J.} and Veerle Bergink and Bastiaansen, {Anna E.} and Schreurs, {Marco W.J.} and Ophoff, {Roel A.} and Boks, {Marco P.} and Kahn, {Ren{\'e} S.} and {de Witte}, {Lot D.}",

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year = "2018",

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doi = "10.1016/j.psychres.2017.10.043",

language = "English",

volume = "259",

pages = "460--462",

journal = "Psychiatry Research",

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T1 - No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder

AU - Snijders, Gijsje

AU - Titulaer, Maarten J.

AU - Bergink, Veerle

AU - Bastiaansen, Anna E.

AU - Schreurs, Marco W.J.

AU - Ophoff, Roel A.

AU - Boks, Marco P.

AU - Kahn, René S.

AU - de Witte, Lot D.

PY - 2018/1

Y1 - 2018/1

N2 - A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.

AB - A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.

KW - Antibodies

KW - Autoimmune

KW - Bipolar disorder

KW - Encephalitis

KW - Immunology

KW - Mania

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No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder

Abstract

Keywords

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