No Linkage between HLA and Congenital Adrenal Hyperplasia Due to 11-β-Hydroxylase Deficiency

C. Brautbar, A. Rösler, H. Landau, I. Cohen, D. Nelken, T. Cohen, C. Levine, J. Sack, A. Benderli, S. Moses, E. Lieberman, B. Dupont, L. S. Levine, M. I. New

Research output: Contribution to journalLetterpeer-review

34 Scopus citations

Abstract

To the Editor: The various forms of congenital adrenal hyperplasia are caused by different enzymatic deficiencies, each responsible for a given step in the biosynthesis of cortisol or aldosterone (or both). The most frequent forms of this disorder result from deficiencies of the 21-hydroxylase and 11-hydroxylase enzymes.1 These enzymes function sequentially in steroid biosynthesis and therefore may be genetically linked, similar perhaps to the lactose system in Escherichia coli.2 Since close genetic linkage between congenital adrenal hyperplasia, 21-hydroxylase deficiency and the B locus of the HLA system has recently been shown,3 4 5 it was of interest to determine if the.

Original languageEnglish
Pages (from-to)205-206
Number of pages2
JournalNew England Journal of Medicine
Volume300
Issue number4
DOIs
StatePublished - 25 Jan 1979
Externally publishedYes

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