No influence of overweight/obesity on exercise lipid oxidation: A systematic review

Avigdor D. Arad, Anthony J. Basile, Jeanine Albu, Fred J. Dimenna

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Compared to lean counterparts, overweight/obese individuals rely less on lipid during fasting. This deficiency has been implicated in the association between overweight/obesity and blunted insulin signaling via elevated intramuscular triglycerides. However, the capacity for overweight/obese individuals to use lipid during exercise is unclear. This review was conducted to formulate a consensus regarding the influence of overweight/obesity on exercise lipid use. PubMed, ProQuest, ISI Web of Science, and Cochrane Library databases were searched. Articles were included if they presented original research on the influence of overweight/obesity on exercise fuel use in generally healthy sedentary adults. Articles were excluded if they assessed older adults, individuals with chronic disease, and/or exercise limitations or physically-active individuals. The search identified 1205 articles with 729 considered for inclusion after duplicate removal. Once titles, abstracts, and/or manuscripts were assessed, 24 articles were included. The preponderance of evidence from these articles indicates that overweight/obese individuals rely on lipid to a similar extent during exercise. However, conflicting findings were found in eight articles due to the outcome measure cited, participant characteristics other than overweight/obesity and characteristics of the exercise bout(s). We also identified factors other than body fatness which can influence exercise lipid oxidation that should be controlled in future research.

Original languageEnglish
Article number1614
JournalInternational Journal of Molecular Sciences
Issue number5
StatePublished - 1 Mar 2020


  • Exercise lipid oxidation
  • Insulin resistance
  • Insulin signal transduction pathway
  • Intramuscular triglycerides
  • Overweight/obesity
  • Type 2 diabetes


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