No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees

E. Grassi; M. Mortilla; L. Amaducci; S. Pallanti; A. Pazzagli; F. Galassi; B. M. Guarnieri; C. Petruzzi; F. Bolino; L. Ortenzi; R. Nistico; S. De Cataldo; A. Rossi; S. Sorbi

doi:10.1016/S0304-3940(96)12463-0

No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees

E. Grassi, M. Mortilla, L. Amaducci, S. Pallanti, A. Pazzagli, F. Galassi, B. M. Guarnieri, C. Petruzzi, F. Bolino, L. Ortenzi, R. Nistico, S. De Cataldo, A. Rossi, S. Sorbi

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders. We have analyzed seven Italian families with schizophrenia and four families with bipolar disorders for a total of 68 individuals; 32 individuals were affected. Diagnoses were made using the structured clinical interview Schedule for Affective Disorders and Schizophrenia, Lifetime version (SADS-L). The results of our study provide no evidence of linkage between alleles at D2 dopamine receptor loci and schizophrenia or bipolar disorders. The markers TH gene and MAO-A gene give slightly positive or negative results suggesting the utility of further analysis on more informative families.

Original language	English
Pages (from-to)	196-198
Number of pages	3
Journal	Neuroscience Letters
Volume	206
Issue number	2-3
DOIs	https://doi.org/10.1016/S0304-3940(96)12463-0
State	Published - 15 Mar 1996
Externally published	Yes

Keywords

Bipolar disorders
D2 dopamine receptor
Linkage analysis
Monoamino oxydase A
Schizophrenia
Tyrosine hydroxylase

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Grassi, E., Mortilla, M., Amaducci, L., Pallanti, S., Pazzagli, A., Galassi, F., Guarnieri, B. M., Petruzzi, C., Bolino, F., Ortenzi, L., Nistico, R., De Cataldo, S., Rossi, A., & Sorbi, S. (1996). No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees. Neuroscience Letters, 206(2-3), 196-198. https://doi.org/10.1016/S0304-3940(96)12463-0

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title = "No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees",

abstract = "Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders. We have analyzed seven Italian families with schizophrenia and four families with bipolar disorders for a total of 68 individuals; 32 individuals were affected. Diagnoses were made using the structured clinical interview Schedule for Affective Disorders and Schizophrenia, Lifetime version (SADS-L). The results of our study provide no evidence of linkage between alleles at D2 dopamine receptor loci and schizophrenia or bipolar disorders. The markers TH gene and MAO-A gene give slightly positive or negative results suggesting the utility of further analysis on more informative families.",

keywords = "Bipolar disorders, D2 dopamine receptor, Linkage analysis, Monoamino oxydase A, Schizophrenia, Tyrosine hydroxylase",

author = "E. Grassi and M. Mortilla and L. Amaducci and S. Pallanti and A. Pazzagli and F. Galassi and Guarnieri, {B. M.} and C. Petruzzi and F. Bolino and L. Ortenzi and R. Nistico and {De Cataldo}, S. and A. Rossi and S. Sorbi",

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doi = "10.1016/S0304-3940(96)12463-0",

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Grassi, E, Mortilla, M, Amaducci, L, Pallanti, S, Pazzagli, A, Galassi, F, Guarnieri, BM, Petruzzi, C, Bolino, F, Ortenzi, L, Nistico, R, De Cataldo, S, Rossi, A & Sorbi, S 1996, 'No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees', Neuroscience Letters, vol. 206, no. 2-3, pp. 196-198. https://doi.org/10.1016/S0304-3940(96)12463-0

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AU - Grassi, E.

AU - Mortilla, M.

AU - Amaducci, L.

AU - Pallanti, S.

AU - Pazzagli, A.

AU - Galassi, F.

AU - Guarnieri, B. M.

AU - Petruzzi, C.

AU - Bolino, F.

AU - Ortenzi, L.

AU - Nistico, R.

AU - De Cataldo, S.

AU - Rossi, A.

AU - Sorbi, S.

PY - 1996/3/15

Y1 - 1996/3/15

N2 - Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders. We have analyzed seven Italian families with schizophrenia and four families with bipolar disorders for a total of 68 individuals; 32 individuals were affected. Diagnoses were made using the structured clinical interview Schedule for Affective Disorders and Schizophrenia, Lifetime version (SADS-L). The results of our study provide no evidence of linkage between alleles at D2 dopamine receptor loci and schizophrenia or bipolar disorders. The markers TH gene and MAO-A gene give slightly positive or negative results suggesting the utility of further analysis on more informative families.

AB - Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders. We have analyzed seven Italian families with schizophrenia and four families with bipolar disorders for a total of 68 individuals; 32 individuals were affected. Diagnoses were made using the structured clinical interview Schedule for Affective Disorders and Schizophrenia, Lifetime version (SADS-L). The results of our study provide no evidence of linkage between alleles at D2 dopamine receptor loci and schizophrenia or bipolar disorders. The markers TH gene and MAO-A gene give slightly positive or negative results suggesting the utility of further analysis on more informative families.

KW - Bipolar disorders

KW - D2 dopamine receptor

KW - Linkage analysis

KW - Monoamino oxydase A

KW - Schizophrenia

KW - Tyrosine hydroxylase

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No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees

Abstract

Keywords

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